Pyridoxine and pyridoxal analogues: new uses
View Patent ↗The invention provides pyridoxal and pyridoxine analogues, pharmaceutical compositions containing pyridoxine and pyridoxal analogues, and methods of administering pharmaceutical compositions containing a therapeutically effective amount of at least one of these analogues. In accordance with the present invention, the pyridoxal and pyridoxine analogues can be used in the treatment or prevention of of heparin induced thrombocytopenia (HIT), stroke, and ischemia, and in the treatment of symptoms thereof. The the pyridoxal and pyridoxine analogues can be used in neuroprotection.
1. A method of inhibiting heparin induced thrombocytopenia in a mammalian patient comprising administering a therapeutically effective amount of a compound of Formula V:
or a pharmaceutically acceptable acid addition salt thereof, wherein:
R 5 is CH 2 OH or CHO;
R 1 is
n is an integer of 1 to 5;
R 2 , R 3 , and R 4 are each independently
hydrogen;
alkyl;
aryl or biaryl,
wherein the aryl or biaryl can be substituted with a cyano, alkyl, alkoxy, amino, hydroxy, halo, nitro, or alkanoyloxy;
amino;
acylamino;
anilino,
wherein the aniline ring can be substituted with a cyano, alkyl, alkoxy, amino, hydroxy, halo, nitro, or alkanoyloxy;
nitro; or
guanidino.
2. The method of claim 1 wherein said compound is administered to induce a plasma level of said compound of about 100 nM to 10,000 μM.
3. The method of claim 1 wherein said therapeutically effective dose is about 0.1 to 100 mg/kg body weight per day.
4. The method of claim 1 , wherein said compound is administered intravenously, orally, sublingually, intraperitoneally, transdermally, intramuscularly or subcutaneously.
5. The method of claim 1 wherein the compound is
6. The method of claim 1 , wherein heparin-induced thrombus formation is reduced.
7. The method of claim 1 , wherein said compound is administered intravenously.
8. The method of claim 1 , wherein said compound is administered orally.
9. The method of claim 1 , wherein said compound is administered in combination with a pharmaceutically acceptable carrier.
10. The method of claim 1 , said compound is administered in combination with a pharmaceutically acceptable additive.
11. The method of claim 1 wherein said compound is administered to induce a plasma level of said compound of about 1 μM to 1000 μM.
12. The method of claim 1 wherein said compound is administered to induce a plasma level of said compound of about 300 μM to 700 μM.
13. The method of claim 1 wherein said compound is administered to induce a plasma level of said compound of about 450 μM to 550 μM.
14. The method of claim 1 wherein said therapeutically effective dose is about 10 to 100 mg/kg body weight per day.
15. The method of claim 1 wherein said therapeutically effective dose is about 20 to 80 mg/kg body weight per day.
16. The method of claim 1 wherein said compound is administered intravenously at a dose of about 2 to 100 mg/kg body weight.
17. The method of claim 16 , wherein said dose is administered one, two, three, or four times per day.