Use of nitroderivatives in urinary incontinence
View Patent ↗The present invention relates to the use of the following compounds, their compositions, and their salts for the preparation of medicaments for the treatment of urinary incontinence and other diseases, the compounds having the general formula: A-X 1 —NO 2 wherein: A=RCO(X) t , wherein t is the integer 0 or 1; X═O, NH, NR 1C , wherein R 1C is a linear or branched C 1 to C 10 alkyl group; when t=1, R= and X 1 =—YO—, wherein Y is a C 1 to C 20 alkylene, C 5 to C 7 cycloalkyl or oxyalkyl derivative.
1. A compound having the general formula:
A-X 1 —NO 2
or a salt thereof, wherein:
A=RCO
R is selected from:
wherein R V AC1 can be phenyl or cyclohexane,
wherein X 4 can be sulfur or oxygen,
X 1 is a bivalent connecting bridge selected from:
YO, wherein
Y is linear or branched C 2 to C 20 alkylene, or an optionally substituted cycloalkylene having 5 to 7 carbon atoms,
wherein n3 is an integer from 0 to 3,
wherein nf′ is an integer from 1 to 6, or
wherein R 1f —H, CH 3 and nf is an integer from 1 to 6.
2. The compound or a salt thereof according to claim 1 , wherein Y is linear or branched C 2 to C 5 alkylene.
3. The compound or a salt thereof according to claim 1 , wherein V Ac1 is N-[(2-phenoxy-4-nitro)phenyl]-N-(6-nitroxy)hexanoylmethane-sulphonamide.
4. A pharmaceutical composition comprising a pharmaceutically effective amount of the compound according to claim 2 and a pharmaceutically acceptable carrier.