Endoparasiticidal gel composition
View Patent ↗A homogenous, clear, veterinary gel composition which has a broad spectrum of efficacy against endoparasites over a prolonged period of time and which allows for higher concentrations of a mixture of parasiticidal agents in a single application. This composition is useful for treating and controlling endoparasiticidal infection and infestation in a homeothermic animal.
1. A method for the treatment and control of endoparasitic infection and infestation in an equid which comprises orally administering to said equid an effective amount of a non-aqueous endoparasiticidal gel composition which comprises about 1.0% to 3.5% wt/wt of moxidectin and about 10.0% to 15.0% wt/wt of praziquantel; about 4.0% to 24.0% wt/wt of benzyl alcohol; about 1.0% to 34.0% wt/wt of ethanol; about 2.0% to 15.0% wt/wt of colloidal silicon dioxide; about 1.0% to 20.0% wt/wt of a surfactant; and about 35.0% to 61.0% wt/wt of an oil, wherein said composition is an oral gel.
2. The method according to claim 1 wherein said composition is administered to provide said equid with moxidectin in an amount of about 0.3 mg/kg to 0.5 mg/kg of moxidectin per body weight.
3. The method according to claim 2 wherein the amount of moxidectin is about 0.4 mg/kg of moxidectin per body weight.
4. The method according to claim 3 wherein the amount of praziquantel is about 2.5 mg/kg of praziquantel per body weight.
5. The method according to claim 1 wherein said composition is administered to provide said equid with praziquantel in an amount of 2.0 mg/kg to 3.0 mg/kg of praziquantel per body weight.
6. The method according to claim 1 , wherein moxidectin is present in an amount of about 1.5% to 2.5% wt/wt.
7. The method according to claim 1 , wherein praziquantel is present in an amount of about 12% to 13% wt/wt.
8. The method according to claim 1 , wherein the oil is propylene glycol dicaprylate/dicaprate or dicaprylic/dicapric triglyceride.
9. The method according to claim 1 , wherein the surfactant comprises a polyoxyethylene sorbitan ester.
10. The method according to claim 9 , wherein said ester is polysorbate 80.