Lubricious, biocompatible coatings for medical devices
A lubricous coating composition and methods for using same are provided. Specifically, a composition suitable for providing hydrophobic polymer surfaces with lubricious coatings is described wherein a polyolefin surface is reiteratively treated with hydrophilic polymer solutions and cross-linking solutions. Methods for reiterative coating polymer surfaces are also provided including methods wherein the hydrophobic polymer surface is pretreated using plasma energy.
1 . A lubricious coating for a medical device comprising:
at least one first lubricious polymer applied to at least one surface of said medical device;
at least one cross-linking agent applied to said first lubricious polymer on said surface; and
a second lubricous polymer applied to said at least one cross-linking agent applied to said surface and said first lubricious polymer;
wherein said first and said second lubricous polymer can be the same or different.
2 . The lubricious coating for a medical device according to claim 1 wherein said medical device is a polyolefin intraocular lens inserter tip.
3 . The lubricious coating for a medical device according to claim 1 wherein said cross-linking agent is glutaraldehyde.
4 . The lubricious coating for a medical device according to claim 1 wherein said lubricous polymer is polyvinylpyrrolidone.
5 . The lubricious coating for a medical device according to claim 4 wherein said lubricous polymer further comprises polyethylenimine.
6 . A method for providing a medical device surface with a lubricious coating comprising:
applying at least one first lubricious polymer to at least one surface of said medical device;
cross-linking said at least one first lubricious polymer using at least one cross-linking agent applied to said first lubricious polymer on said surface; and
applying a second lubricous polymer to said at least one cross-linked first lubricious polymer;
wherein said first and said second lubricous polymer can be the same or different.
7 . The method for providing a medical device with a lubricious coating according to claim 6 further comprising the step of plasma treating said at least one surface prior to applying said at least one first lubricious polymer.
8 . The method for providing a medical device with a lubricious coating according to claim 6 wherein said medical device is a polyolefin intraocular lens inserter tip.
9 . The method for providing a medical device with a lubricious coating according to claim 6 wherein said cross-linking agent is glutaraldehyde.
10 . The method for providing a medical device with a lubricious coating according to claim 6 wherein said lubricous polymer is polyvinylpyrrolidone.
11 . The method for providing a medical device with a lubricious coating according to claim 10 wherein said lubricous polymer further comprises polyethylenimine.
12 . The method for providing a medical device with a lubricious coating according to claim 6 wherein said applying is done using a method selected from the group consisting of spraying, dipping, brushing and coating.
13 . A method for providing a polyolefin intraocular lens (IOL) inserter tip surface with a lubricious coating comprising:
a) plasma treating said surface;
b) applying a lubricous coating solution comprising polyethylenimine and polyvinylpyrrolidone;
c) drying said surface;
d) applying a glutaraldehyde solution to said dried surface to form a cross-linked lubricious coating;
e) drying said cross-linked lubricious coating;
f) applying said lubricous coating solution to said dried cross-linked lubricious coating to form a coated IOL inserter tip; and
g) drying said coated IOL inserter tip.
14 . The method for providing a medical device with a lubricious coating according to claim 13 wherein said lubricous coating solution further comprises stannous ethylhexanoate.
15 . The method for providing a medical device with a lubricious coating according to claim 13 further comprising sterilizing said coated IOL inserted tip.