Methods of using
View Patent ↗The present invention uses pharmaceutical preparations of Botulinum toxin to induce neurogenic atrophy to alter muscle volume and subsequently, facial contour. Reduction in lip volume is accomplished using the disclosed methods thereby producing a favorable effect on a hypervolemic lip deformity. In other embodiments of the invention, the methods disclosed herein may be used to shrink muscle bulk and contour, especially in the face. In one embodiment, treating excessive muscle bulk below the eyelids can cause a smoothing of the lower lid and cheek contour producing a favorable improvement in appearance. Such an application is in distinct contrast to rhytide (wrinkle reduction) as the injected region does not contain wrinkles or any other form of dynamic line, merely excessive tissue bulk.
1. A method for reducing lip volume in a subject in need of reduced lip volume, comprising the steps of: assessing lip volume, administering a therapeutically effective amount of a pharmaceutical preparation of Botulinum toxin to one or both of the lips of said subject to thereby induce reduced lip volume in one or both of the upper and lower lips of said subject, and assessing lip volume after said administration.
2. The method of claim 1 , wherein said pharmaceutical preparation is administered to the orbicularis oris muscle of said subject.
3. The method of claim 1 , wherein said pharmaceutical preparation is administered to the lip retractors.
4. The method of claim 1 , wherein said subject has a hypervolemic lip deformity.
5. The method of claim 1 , wherein the pharmaceutical preparation of Botulinum toxin comprises any combination of more than one of immunotypes A, B, C, D, B, F and G.
6. The method of claim 1 , wherein about 5 to about 2000 Lethal Dose 50 (LD 50 ) units of Botulinum toxin are administered to said subject.
7. The method of claim 1 , wherein the pharmaceutical preparation of Botulinum toxin is administered via transcutaneous or transmucosal injection.
8. The method of claim 1 , wherein the pharmaceutical preparation of Botulinum toxin is administered via multifocal injection.