Benzimidazoles

1. A compound according to formula IAb:

wherein

Ab represents a pyrazolyl radical substituted with a radical chosen from —NH—C(═O)NY 1 bY 2 b, acylamino(NH—CO—R 6 b), and —NH—C(═O)R 6 b, with NY 1 bY 2 b such that either Y 1 b and Y 2 b, which may be identical or different, are chosen from hydrogen and optionally substituted alkyl, cycloalkyl, cycloalkylalkyl, phenyl, naphthyl, phenoxy, phenylalkyl, phenylalkylthio and naphthylalkyl or Y 1 b and Y 2 b form, together with the nitrogen atom to which they are attached, a piperidyl, hexahydrofuran, morpholinyl or morpholinylalkyl radical;

A 1 b and A 4 b are hydrogen;

A 2 b and A 3 b, which may be identical or different, are chosen from a hydrogen atom, halogen atoms, hydroxyl, alkyl, alkenyl, alkoxy, nitro, cyano, furyl, thienyl, benzothienyl, naphthyl, thianthrenyl, phenyl and phenoxy radicals and a carboxyl radical which is free, salified, esterified with an alkyl radical or amidated with a radical NA 6 bA 7 b such that either A 6 b and A 7 b, which may be identical or different, are chosen from hydrogen and alkyl, alkoxyalkyl, phenoxyalkyl, phenyl, phenylalkyl, cycloalkylalkyl, cycloalkyl, furylalkyl, naphthylalkyl, thienylalkyl, piperidylalkyl, pyridylalkyl, benzothienylalkyl, pyrazolylalkyl, dihydrobenzofuranylalkyl, hexahydropyranylalkyl, ethylenedioxyphenylalkyl and benzimidazolylalkyl radicals, all these radicals being optionally substituted, or A 6 b and A 7 b form, together with the nitrogen atom to which they are attached, a pyrrolidinyl, morpholino or piperazinyl radical, the piperazinyl radical being optionally substituted on the second nitrogen atom with an alkyl radical itself optionally substituted,

it being understood that A 2 b and A 3 b can form, with the benzimidazole radical to which they are attached, an optionally substituted 4,5-ethylenedioxybenzimidazole radical or an optionally substituted 4,5-methylenedioxybenzimidazole radical;

A 5 b represents a hydrogen atom;

all the above radicals containing alkyl, alkenyl, phenyl, phenoxy, furyl, thienyl, piperidyl, pyridyl, pyrazolyl and benzimidazolyl being optionally substituted with one or more radicals chosen from halogen atoms and hydroxyl, cyano, alkyl, alkoxy, amino, alkylamino, dialkylamino, phenylamino, phenylalkylamino, acylamino(NH—COR 6 b), —C(═O)OR 6 b, acyl —C(═O)R 6 b, hydroxyalkyl, carboxyalkyl, phenoxyalkyl, S(O) n -alk, S(O) n —NH 2 , S(O) n —NH(alk), S(O) n —N(alk) 2 , CF 3 , OCF 3 , NO 2 , CN, phenyl, itself optionally substituted with one or more halogen atoms, thienyl, phenoxy, phenylalkoxy, —C(═O)—NH 2 , —C(═O)—NH(alk) or C(═O)—N(alk) 2 radicals;

with n representing an integer from 0 to 2,

and R 6 b representing hydrogen,

all the phenyl radicals of the above radicals furthermore being optionally substituted with a dioxole radical; or

a racemic, enantiomeric or diastereoisomeric isomer form of such compound, or an addition salt with a mineral or an organic acid or with a mineral base of such compound.

2. A compound according to claim 1 wherein when one of A 2 b and A 3 b represents a carboxyl radical amidated with a radical NA 6 bA 7 b, then either one of A 6 b and A 7 b represents a hydrogen atom or an alkyl radical and the other of A 6 b and A 7 b is chosen from the values defined for A 6 b and A 7 b, or A 6 b and A 7 b form, together with the nitrogen atom to which they are attached, a 5- or 6-membered cyclic radical; or

a racemic, enantiomeric or diastereoisomeric isomer form of such compound, or an addition salt with a mineral or an organic acid or with a mineral base of such compound.

3. A compound according to claim 1 wherein A 2 b and A 3 b optionally form a dioxole radical;

or a racemic, enantiomeric or diastereoisomeric isomer form of such compound, or an addition salt with a mineral or an organic acid or with a mineral base of such compound.

4. A pharmaceutical composition comprising a pharmaceutically effective amount of a compound according to claim 1 , together with one or more pharmaceutically acceptable carriers or excipients.

5. A pharmaceutical composition comprising a pharmaceutically effective amount of a compound according to claim 2 , together with one or more pharmaceutically acceptable carriers or excipients.

6. A pharmaceutical composition comprising a pharmaceutically effective amount of a compound according to claim 3 , together with one or more pharmaceutically acceptable carriers or excipients.

7. A compound of claim 1 , wherein said compound is according to formula Ixa:

wherein

W represents CH;

X represents CH or CR 2 ;

Y represents CH or CR 3 ;

Z represents CH;

R 2 and R 3 each represents, independently, H, carboxy, cyano, halo, haloalkyl, hydroxy, nitro, R 4 , —C(═O)R 4 , —C(═O)NY 1 Y 2 , —C(═O)OR 4 , —NY 1 Y 2 , —N(R 6 )C(═O)R 4 , —N(R 6 )C(═O)NY 1 Y 2 , —N(R 6 )C(═O)OR 4 , —N(R 6 )SO 2 R 4 , —N(R 6 )SO 2 NY 1 Y 2 , —OR 4 , —OCF 2 H, —OCF 3 , —OC(═O)R 4 , —OC(═O)NY 1 Y 2 , —S(O) n R 4 , —S(O) n NY 1 Y 2 or —S(O) n OR 4 ; or

R 2 represents H, carboxy, cyano, halo, haloalkyl, hydroxy, nitro, R 4 , —C(═O)R 4 , —C(═O)NY 1 Y 2 , —C(═O)OR 4 , —NY 1 Y 2 , —N(R 6 )C(═O)R 4 , —N(R 6 )C(═O)NY 1 Y 2 , —N(R 6 )C(═O)OR 4 , —N(R 6 )SO 2 R 4 , —N(R 6 )SO 2 NY 1 Y 2 , —OR 4 , —OCF 2 H, —OCF 3 , —OC(═O)R 4 , —OC(═O)NY 1 Y 2 , —S(O) n R 4 , —S(O) n NY 1 Y 2 or —S(O) n OR 4 and R 3 represents alkyl, haloalkyl, halogen or OR 6 ; or

R 2 and R 3 form a group selected from —O—CH 2 —O—, —O—CH 2 —CH 2 —O—; —CH 2 —O—CH 2 —, —CH 2 —CH 2 —CH 2 —, —CH 2 —C(CH 3 ) 2 —CH 2 —, —CH 2 —O—CH 2 —CH 2 —, —CH 2 —CH 2 —CH 2 —CH 2 —, and —CH 2 —C(CH 3 ) 2 —CH 2 —CH 2 —;

R 4 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, each optionally substituted with one or more substituents selected from alkyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, halo, hydroxy, hydroxyalkyl, —C(═O)NY 3 Y 4 , —C(═O)OR 6 , —N(R 6 )C(═O)NY 1 Y 2 , —NY 1 Y 2 , —OR 5 or alkyl substituted by —NY 3 Y 4 ;

R 5 and R 6 each is, independently, alkyl, alkenyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl;

n is zero or an integer 1 or 2;

Y 1 and Y 2 are independently hydrogen, alkenyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, heterocycloalkylalkyl or alkyl optionally substituted by one or more groups selected from cyano, aryl, heteroaryl, hydroxy, —C(═O)OR 6 , —C(═O)NY 3 Y 4 , —NY 3 Y 4 or —OR 5 , or the group —NY 1 Y 2 may form a cyclic amine;

Y 3 and Y 4 are independently hydrogen, alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl or heteroarylalkyl; or the group —NY 3 Y 4 may form a cyclic amine;

R7 represents hydrogen;

R8 represents hydrogen; and

R9 represents —NHC(═O)R 4′ , in which said —NHC(═O)R 4′ is:

or a racemic, enantiomeric or diastereoisomeric isomer form of such compound, or an addition salt with a mineral or an organic acid or with a mineral base of such compound.

8. A compound of claim 7 , wherein:

X represents CH; and

Y represents:

or a racemic, enantiomeric or diastereoisomeric isomer form of such compound, or an addition salt with a mineral or an organic acid or with a mineral base of such compound.

9. A compound of claim 7 , wherein:

X represents C—CH 3 , C—CH 2 CH 3 , C—CH(CH 3 ) 2 , C—OCH 3 , C—OCH 2 CH 3 , C—Br or C—Cl; and

Y represents C—CH 3 , C—CH 2 CH 3 , C—OCH 3 , C—Br, C—Cl, C—F,

or a racemic, enantiomeric or diastereoisomeric isomer form of such compound, or an addition salt with a mineral or an organic acid or with a mineral base of such compound.

10. A compound of claim 7 , wherein:

X represents CR 2 and Y represents CR 3 , where R 2 and R 3 form the group —CH 2 —O—CH 2 —;

or a racemic, enantiomeric or diastereoisomeric isomer form of such compound, or an addition salt with a mineral or an organic acid or with a mineral base of such compound.

11. A compound of claim 7 , wherein:

X represents CR 2 and Y represents CR 3 , where R 2 and R 3 form the group —CH 2 —CH 2 —CH 2 —;

or a racemic, enantiomeric or diastereoisomeric isomer form of such compound, or an addition salt with a mineral or an organic acid or with a mineral base of such compound.

12. A compound of claim 7 , wherein:

X represents CH; and

Y represents CH;

Or a racemic, enantiomeric or diastereoisomeric isomer form of such compound, or an addition salt with a mineral or an organic acid or with a mineral base of such compound.

13. A compound of claim 7 , wherein said compound is:

or a racemic, enantiomeric or diastereoisomeric isomer form of such compound, or an addition salt with a mineral or an organic acid or with a mineral base of such compound.

14. A pharmaceutical composition comprising a pharmaceutically effective amount of a compound according to claim 7 , together with one or more pharmaceutically acceptable carriers or excipients.

15. A pharmaceutical composition comprising a pharmaceutically effective amount of a compound according to claim 8 , together with one or more pharmaceutically acceptable carriers or excipients.

16. A pharmaceutical composition comprising a pharmaceutically effective amount of a compound according to claim 9 , together with one or more pharmaceutically acceptable carriers or excipients.

17. A pharmaceutical composition comprising a pharmaceutically effective amount of a compound according to claim 12 , together with one or more pharmaceutically acceptable carriers or excipients.

18. A pharmaceutical composition comprising a pharmaceutically effective amount of a compound according to claim 13 , together with one or more pharmaceutically acceptable carriers or excipients.