Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
View Patent ↗The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.
1. A compound selected from
(3R,4S,3′R)-6-[4-(4-Amino-5-chloro-2-methoxy-benzoylamino)-3-methoxy-piperidin-1-yl]-hexanoic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester
and pharmaceutically acceptable salts thereof.
2. A compound selected from
(3S,4R,3′R)-6-[4-(4-Amino-5-chloro-2-methoxy-benzoylamino)-3-methoxy-piperidin-1-yl]-hexanoic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester
and pharmaceutically acceptable salts thereof.
3. A compound selected from
(3R,4S,3′S)-6-[4-(4-Amino-5-chloro-2-methoxy-benzoylamino)-3-methoxy-piperidin-1-yl]-hexanoic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester
and pharmaceutically acceptable salts thereof.
4. A compound selected from
(3S,4R,3′S)-6-[4-(4-Amino-5-chloro-2-methoxy-benzoylamino)-3-methoxy-piperidin-1-yl]-hexanoic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester
and pharmaceutically acceptable salts thereof.
5. The composition according to claim 1 wherein the compound is a dihydrochloride salt form.
6. The composition according to claim 2 wherein the compound is a dihydrochloride salt form.
7. The composition according to claim 3 wherein the compound is a dihydrochloride salt form.
8. The composition according to claim 4 wherein the compound is a dihydrochloride salt form.
9. A composition comprising the compound according to claim 1 wherein the compound is present in at least about 90% stereoisomeric excess.
10. A composition comprising the compound according to claim 2 wherein the compound is present in at least about 90% stereoisomeric excess.
11. A composition comprising the compound according to claim 3 wherein the compound is present in at least about 90% stereoisomeric excess.
12. A composition comprising the compound according to claim 4 wherein the compound is present in at least about 90% stereoisomeric excess.
13. A composition comprising the compound according to claim 5 wherein the compound is present in at least about 90% stereoisomeric excess.
14. A composition comprising the compound according to claim 6 wherein the compound is present in at least about 90% stereoisomeric excess.
15. A composition comprising the compound according to claim 7 wherein the compound is present in at least about 90% stereoisomeric excess.
16. A composition comprising the compound according to claim 8 wherein the compound is present in at least about 90% stereoisomeric excess.
17. A composition comprising the compound according to claim 1 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.
18. A composition comprising the compound according to claim 2 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.
19. A composition comprising the compound according to claim 3 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.
20. A composition comprising the compound according to claim 4 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.
21. A composition comprising the composition according to claim 5 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.
22. A composition comprising the composition according to claim 6 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.
23. A composition comprising the composition according to claim 7 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.
24. A composition comprising the composition according to claim 8 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.
25. A composition comprising the compound according to claim 9 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.
26. A composition comprising the compound according to claim 10 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.
27. A composition comprising the compound according to claim 11 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.
28. A composition comprising the compound according to claim 12 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.
29. A composition comprising the composition according to claim 13 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.
30. A composition comprising the composition according to claim 14 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.
31. A composition comprising the composition according to claim 15 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.
32. A composition comprising the composition according to claim 16 and a pharmaceutically acceptable excipient, adjuvant, carrier, or solvent.