Blood processing systems and methods that alternate flow of blood component and additive solution through an in-line leukofilter
View Patent ↗Blood processing systems and methods convey blood cells from a blood cell source into a blood component collection flow channel that includes a blood cell storage container and an in-line filter to remove leukocytes from blood cells before entering the blood cell storage container. The systems and methods also convey additive solution from an additive solution source into the blood component collection flow channel. The systems and methods alternate the conveyance of blood cells through the filter with the conveyance of additive solution through the filter.
1. A blood processing system comprising
a source of blood cells,
a blood cell storage container,
a source of an additive solution for blood cells,
a blood component collection flow channel communicating with the blood cell storage container and including an in-line filter to remove leukocytes from blood cells before entering the blood cell storage container,
a pumping mechanism communicating with the blood component collection flow channel and operable in different modes, and
a controller is programmed to operate the pumping mechanism in such different modes, including a first mode to convey blood cells from the blood cell source into the blood component collection flow channel and a second mode for conveying additive solution from the additive solution source directly into the blood component collection flow channel, the controller is programmed to alternate the pumping mechanism between the first and second modes.
2. A system according to claim 1
wherein the controller is operable to alternate the pumping mechanism between the first and second modes to achieve a desired ratio between blood cell volume and additive solution volume in the blood cell storage container.
3. A system according to claim 1
wherein the controller is operable to terminate the first mode when a desired volume of blood cells has been conveyed from the blood cell source and operates the pumping mechanism in the second mode to flush residual blood cells from the filter into the red blood cell storage container.
4. A system according to claim 1
wherein the pumping mechanism includes a fluid pressure actuated pump and an actuator to apply fluid pressure to the pump.
5. A system according to claim 1
wherein the pumping mechanism includes a fluid pressure actuated pump housed within a cassette and an external actuator to receive the cassette and operate the fluid pressure actuated pump, and
wherein the controller is coupled to the external actuator.
6. A system according to claim 1
wherein the filter includes a fibrous filter medium.
7. A system according to claim 1
wherein the filter includes a filter medium and a housing enclosing the filter medium.
8. A system according to claim 7
wherein the housing comprises a flexible material.
9. A system according to claim 8
further including a fixture to restrain expansion of the housing during operation of the pumping mechanism.
10. A system according to claim 1
wherein the controller includes a function to derive a value reflecting volume of blood cells present in the blood cell collection container after passage through the filter as a percentage of volume of blood cells conveyed from the red blood cell source to the filter.
11. A system according to claim 1
wherein the blood cells comprise red blood cells.