IP Library › Granted Patent US 7,081,476
Granted Patent B2
US 7,081,476 · App. 11/038,373 · Granted Jul 25, 2006

Tocopherol enriched compositions for reducing IL6 levels

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Quick Facts
Patent No.
US 7,081,476
App. No.
11/038,373
Granted
Jul 25, 2006
Kind
B2
Abstract

Non-alpha-tocopherol enriched tocopherol compositions and non-alpha metabolite enriched compositions are disclosed for use in the reduction of the inflammatory marker IL-6.

Claims (20)

1. A method of reducing the level of IL-6 in an individual subject to an IL-6 associated inflammatory condition comprising administering to the individual an effective amount of non-alpha-tocopherol enriched tocopherol composition, wherein said non-alpha tocopherol is selected from the group consisting of gamma-tocopherol, beta-tocopherol and delta-tocopherol, and wherein said composition comprises less than 30% alpha-tocopherol.

2. The method of claim 1 wherein said non-alpha-tocopherol is gamma-tocopherol.

3. The method of claim 1 wherein said non-alpha tocopherol is beta-tocopherol.

4. The method of claim 1 wherein said non-alpha-tocopherol is delta-tocopherol.

5. The method of claim 1 wherein said composition further comprises a pharmaceutically acceptable carrier.

6. The method of claim 5 wherein said composition is formulated to be a topical composition.

7. The method of claim 1 wherein said inflammatory condition is an inflammatory skin condition.

8. The method of claim 1 wherein said composition comprises less than 25% alpha-tocopherol.

9. The method of claim 8 wherein said composition comprises less than 20% alpha-tocopherol.

10. The method of claim 9 wherein said composition comprises less than 15% alpha-tocopherol.

11. The method of claim 10 wherein said composition comprises less than 10% alpha-tocopherol.

12. The method of claim 11 wherein said composition comprises less than 5% alpha-tocopherol.

13. A method of reducing the level of IL-6 in an individual subject to an IL-6 associated inflammatory condition comprising administering to the individual an effective amount of non-alpha-tocopherol enriched tocopherol composition, wherein said composition comprises at least 60% gamma-tocopherol, at least 28% delta-tocopherol and no greater than 10% alpha-tocopherol.

14. A method of reducing the level of IL-6 in an individual subject to an IL-6 associated inflammatory condition comprising administering to the individual an effective amount of a metabolite of a non-alpha-tocopherol selected from the group consisting of a beta-tocopherol metabolite, a gamma-tocopherol metabolite and a delta-tocopherol metabolite.

15. The method of claim 14 wherein said non-alpha-tocopherol is a gamma-tocopherol metabolite.

16. The method of claim 15 wherein said gamma-tocopherol metabolite is 2,7,8-trimethyl-2-(2′-carboxyethyl)-6-hydroxychroman (gamma-CEHC).

17. The method of claim 14 wherein said non-alpha tocopherol is a beta-tocopherol metabolite.

18. The method of claim 17 wherein said beta-tocopherol metabolite is 2,5,8-trimethyl-2-(2-carboxyethyl)-6-hydroxychroman (beta-CEHC).

19. The method of claim 14 wherein said non-alpha-tocopherol is a delta-tocopherol metabolite.

20. The method of claim 19 wherein said delta-tocopherol metabolite is 2,8,-dimethyl-2-(2-carboxyethyl)-6-hydroxychroman (delta-CEHC).

Assignments (9)
MERGER Recorded Jan 27, 2022
From: CHENANGO ZERO LLC
To: CHENANGO TWO LLC
Reel/Frame 058888/0133 →
MERGER AND CHANGE OF NAME Recorded Jan 27, 2022
From: CHENANGO TWO LLC; CURRAHEE HOLDING COMPANY INC.
To: JOHNSON & JOHNSON CONSUMER INC.
Reel/Frame 058888/0210 →
MERGER Recorded Jan 27, 2022
From: JOHNSON & JOHNSON CONSUMER INC.
To: CHENANGO ZERO LLC
Reel/Frame 059618/0521 →
CORRECTIVE ASSIGNMENT TO CORRECT THE MERGED ENTITY' NEW NAME PREVIOUSLY RECORDED AT REEL: 036041 FRAME: 0605. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER & CHANGE OF NAME. Recorded Jul 21, 2015
From: JOHNSON & JOHNSON CONSUMER COMPANIES, LLC
To: JOHNSON & JOHNSON CONSUMER INC.
Reel/Frame 036143/0449 →
MERGER Recorded Jul 1, 2015
From: JOHNSON & JOHNSON CONSUMER COMPANIES, INC.
To: JOHNSON & JOHNSON CONSUMER COMPANIES, LLC
Reel/Frame 036043/0978 →
MERGER AND CHANGE OF NAME Recorded Jul 1, 2015
From: JOHNSON & JOHNSON CONSUMER COMPANIES, LLC; JOHNSON & JOHNSON CONSUMER INC.
To: JOHNSON & JOHNSON CONSUMER INC
Reel/Frame 036041/0605 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 20, 2006
From: GALILEO PHARMACEUTICALS, INC.
To: JOHNSON & JOHNSON CONSUMER COMPANIES, INC.
Reel/Frame 018407/0725 →
RELEASE OF SECURITY INTEREST Recorded Sep 29, 2006
From: ALLOY VENTURES, INC., AS SECURED PARTY AND AS COLLATERAL AGENT FOR ADDITIONAL SECURED PARTIES UNDER THE SECURED NOTE PURCHASE AGREEMENT DATED AS OF DECEMBER 22, 2005
To: GALILEO PHARMACEUTICALS, INC.
Reel/Frame 018323/0228 →
SECURITY AGREEMENT Recorded Dec 22, 2005
From: GALILEO PHARMACEUTICALS, INC.
To: ALLOY VENTURES, INC.
Reel/Frame 016936/0079 →