Devices, systems, and methods for closure of cardiac openings
The invention generally relates to devices, systems, and methods for percutaneous closure of cardiac openings and obliteration of the cardiac cul-de-sacs. In one embodiment, a closure device includes a patch with an adhesive and/or a removable frame. The patch may be placed across a cardiac opening, such as a patent foramen ovale, or across a cardiac cul-de-sac, such as a left atrial appendage. In another embodiment, a closure device includes a balloon together with adhesives and/or substances for stimulating tissue growth coated on, or contained within, the balloon. The balloon may be inserted into a cardiac opening, such as the patent foramen ovale, or into a cardiac cul-de-sac, such as a left atrial appendage.
1 . A system for percutaneous transluminal closure of a cardiac opening, comprising:
a balloon for application of an adhesive comprising an outer surface, the balloon transitionable between a deflated state and an inflated state;
a catheter comprising a length between a proximal end and a distal end, wherein said balloon is joined to the distal end of the catheter; and
a first locator joined to said catheter, wherein said locator positions said balloon in said cardiac opening.
2 . The system of claim 1 , wherein the first locator comprises a disk.
3 . The system of claim 1 , wherein the first locator comprises a plurality of arms.
4 . The system of claim 1 , wherein the first locator comprises a rod.
5 . The system of claim 1 , wherein the first locator comprises a locator balloon.
6 - 7 . (canceled)
8 . The system of claim 1 further comprising a second locator coupled to at least one of the catheter and the balloon, the second locator for positioning the closure device in the cardiac opening.
9 . The system of claim 1 further comprising an adhesive coated on the first locator.
10 . (canceled)
11 . The system of claim 1 , wherein the adhesive comprises a cyanoacrylate.
12 . The system of claim 1 , wherein the adhesive comprises a fibrin based adhesive.
13 . The system of claim 1 , wherein the adhesive comprises an albumin gluteraldehyde type adhesive.
14 . (canceled)
15 . The system of claim 8 further comprising an adhesive coated on the second locator.
16 - 18 . (canceled)
19 . The system of claim 1 , wherein the adhesive comprises a light activated adhesive.
20 . The system of claim 1 further comprising a light source coupled to the catheter for activating the light activated adhesive.
21 . The system of claim 1 further comprising an adhesive coated on an outer surface of the balloon.
22 . (canceled)
23 . The system of claim 1 , wherein the balloon is tubular-shaped.
24 . The system of claim 1 , wherein the balloon comprises a plurality of holes.
25 . (canceled)
26 . The system of claim 24 , wherein the adhesive is contained within the balloon.
27 . (canceled)
28 . The system of claim 1 , wherein the surface of the balloon is involuted.
29 . The system of claim 1 , wherein the balloon is adapted to deliver the adhesive from the inner lumen of the balloon to the exterior surface of the balloon by capillary action.
30 . The system of claim 1 , wherein the balloon is detachable from the distal end of the catheter.
31 . The system of claim 30 , wherein the first locator is attached to the balloon.
32 . The system of claim 1 , wherein the adhesive comprises an irritant.
33 . The system of claim 1 , wherein the adhesive comprises a tissue growth stimulator.
34 - 226 . (canceled)