Method of making microneedles
View Patent ↗A method of making a microneedle array structure ( 20 ) comprising a plurality of simultaneously formed microneedles ( 24 ), each microneedle ( 24 ) having a protrusion ( 32 ) and a passageway ( 34 ) extending therethrough. The method comprises the steps of pressing an embossable sheet material between a complimentary tools and radiantly heating the sheet material using radiant energy from a radiant energy source. One tool is relatively-radiantly-transparent, and another tool and/or the sheet material is relatively-radiantly-absorptive.
1. A method of making a microneedle having a protrusion and passageway extending therethrough, said method comprising the steps of:
pressing an embossable, sheet material that is one of radiantly transparent or radiantly absorptive between a first radiant transparent tool having a recess which defines the protrusion and a second tool having a projection which defines the passageway;
wherein the second tool can be radiantly-transparent or radiantly-absorptive; and
radiantly heating the sheet material by using radiant energy from a vertically movable radiant energy source disposed above the first tool and below the second tool;
wherein the first tool is radiantly-transparent and the radiant energy passes there through to the sheet material; and
wherein at least one of the sheet material and the second tool is radiantly-absorptive.
2. A method as set forth in claim 1 , wherein the radiant energy source supplies near-infrared energy.
3. A method as set forth in claim 1 , wherein the radiant energy source includes a blackbody emitter having a temperature of at least 2000 K.
4. A method as set forth in claim 1 , wherein said pressing step is performed by a press comprising an upper press incorporating the first tool and a lower press incorporating the second tool.
5. A method as set forth in claim 1 , wherein said pressing step is performed by a pair of belts comprising an upper belt incorporating the first tool and a lower belt incorporating the second tool.
6. A method as set forth in claim 1 , wherein the first tool is made of a thermoplastic, a thermoset polymer material, glass, or quartz.
7. A method as set forth in claim 1 , wherein the sheet material includes a dopant that increases radiant absorptivity.
8. A method as set forth in claim 7 , wherein the first tool is made of a thermoplastic, a thermoset polymer material, glass, or quartz.
9. A method as set forth in claim 1 , wherein the second tool is made of a thermoplastic, a thermoset polymer material, glass, or quartz.
10. A method as set forth in claim 1 , wherein the first tool comprises a plurality of recesses, and wherein the second tool comprises a plurality of projections, whereby said pressing steps and said radiant heating steps result in a microneedle array structure comprising a plurality of simultaneously formed microneedles.
11. A method as set forth in claim 1 , wherein the recess in the first tool and the projection in the second tool are sized and shaped so that the passageway will extend through the tip of the protrusion.
12. A method as set forth in claim 1 , wherein the recess in the first tool and the projection in the second tool are sized and shaped so that the passageway is centrally located in the protrusion.
13. A method as set forth in claim 1 , wherein the recess in the first tool and the projection in the second tool are sized and shaped so that the passageway does not extend through the tip of the protrusion.
14. A method as set forth in claim 1 , wherein the first tool also has a projection to form an indent surrounding the protrusion.
15. A method of making a microstructure having a protrusion and a passageway extending through the protrusion, said method comprising the steps of:
pressing an embossable sheet material that is one of radiantly transparent or radiantly absorptive between a first tool having a recess which defines the protrusion and a second tool wherein the second tool can be radiantly-transparent or radiantly-absorptive having a projection which defines the passageway; and
radiantly heating the sheet material by using radiant energy from a vertically movable radiant energy source by heaters disposed above the first tool and below the second tool;
wherein the first tool is radiantly-transparent and the radiant energy passes therethrough to the sheet material; and
wherein at least one of the sheet material and the second tool is radiantly-absorptive.
16. A method as set forth in claim 15 , wherein the sheet material is radiantly-transparent and the second tool is radiantly-absorptive.
17. A method as set forth in claim 15 , wherein the sheet material is radiantly-absorptive.