Rapidly dissolving metoclopramide solid oral dosage and method thereof
A solid metoclopramide oral dosage formulation, such as a lyophilized oral dosage, dissolves within the mouth within about 60 seconds or less. This formulation is used for abating manifestations of gastroparesis in a patient, and may be taken with or without water.
1 . A metoclopramide oral dosage formulation comprising a solid oral dosage containing metoclopramide, or a pharmaceutically acceptable salt thereof, wherein the solid oral dosage dissolves within the mouth within a time period of from about 60 seconds or less.
2 . The metoclopramide oral dosage formulation of claim 1 , wherein the time period is from about 30 seconds or less.
3 . The metoclopramide oral dosage formulation of claim 2 , wherein the time period is from about 1 second to about 15 seconds.
4 . The metoclopramide oral dosage formulation of claim 3 , wherein the time period is from about 3 seconds to 15 seconds.
5 . The metoclopramide oral dosage formulation of claim 4 , wherein the time period is from about 3 seconds to 10 seconds.
6 . The metoclopramide oral dosage formulation of claim 5 , wherein the time period is from about 3 seconds to about 5 seconds.
7 . The metoclopramide oral dosage formulation of claim 1 , wherein the metoclopramide oral dosage comprises from about 40 mg of metoclopramide or less.
8 . The metoclopramide oral dosage formulation of claim 7 , wherein the metoclopramide oral dosage comprises about 20 mg of metoclopramide.
9 . The metoclopramide oral dosage formulation of claim 1 , wherein the solid oral dosage formulation comprises a lyophilized dosage form.
10 . The metoclopramide oral dosage formulation of claim 1 , wherein the solid oral dosage formulation comprises a dosage form selected from the group consisting of tablet, pill, capsule and melt.
11 . The metoclopramide oral dosage formulation of claim 1 , wherein the solid oral dosage formulation comprises a dosage form selected from the group consisting of a tablet.
12 . The metoclopramide oral dosage formulation of claim 1 , wherein the solid oral dosage formulation comprises a dosage form selected from the group consisting of a pill.
13 . The metoclopramide oral dosage formulation of claim 1 , wherein the solid oral dosage formulation comprises a dosage form selected from the group consisting of a capsule.
14 . The metoclopramide oral dosage formulation of claim 1 , wherein the solid oral dosage formulation comprises a dosage form selected from the group consisting of a melt.
15 . A process for formulating a lyophilized metoclopramide tablet, comprising the steps of:
forming a solution of metoclopramide; and,
drying by freezing in a high vacuum to form a lyophilized metoclopramide formulation.
16 . A metoclopramide lyophilized tablet product produced by the process of claim 15 .
17 . The metoclopramide lyophilized tablet product of claim 16 , where the metoclopramide comprises a dosage of 10 mg.
18 . A method for abating manifestations of gastroparesis in a patient comprising the steps of:
providing a metoclopramide oral dosage formulation of claim 1; and,
administering the oral dosage formulation effective to dissolve within the mouth within a time period of from about 60 seconds or less.
19 . The method of claim 18 , wherein the step of administering metoclopramide occurs without administration fluids.
20 . The method of claim 19 , wherein the step of administering metoclopramide occurs without administration of water.