IP Library Granted Patent US 7,408,632
Granted Patent B2
US 7,408,632 · App. 11/060,180 · Granted Aug 5, 2008

Miscibility determination of a combination of liquids

Assignee: TransForm Pharmaceuticals, Inc.
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Quick Facts
Patent No.
US 7,408,632
App. No.
11/060,180
Granted
Aug 5, 2008
Kind
B2
Abstract

The present invention provides methods for the determination of miscibility of a mixture of two or more liquids. Measurements of the local deviation of a pattern characteristic or of the variation in light intensity are employed in such determinations.

Claims (58)

1. A method for the determination of miscibility of a mixture of two or more liquids comprising:

(a) preparing said mixture in a container, wherein the shape of said container causes convergence or divergence of transmitted radiation;

(b) placing said container in proximity to a reference pattern;

(c) irradiating said mixture; and

(d) measuring any local deviation of a pattern characteristic of said reference pattern;

wherein said reference pattern is substantially transparent and a substrate for said reference pattern is opaque.

2. A method for the determination of miscibility of a mixture of two or more liquids comprising:

(a) preparing said mixture in a container, wherein the shape of said container causes convergence or divergence of transmitted radiation;

(b) placing said container in proximity to a reference pattern;

(c) irradiating said mixture; and

(d) measuring any local deviation of a pattern characteristic of said reference pattern;

wherein said local deviation is measured following transmission of radiation through said container followed by said reference pattern.

3. A method for the determination of miscibility of a mixture of two or more liquids comprising:

(a) preparing said mixture in a container, wherein the shape of said container causes convergence or divergence of transmitted radiation;

(b) placing said container in proximity to a reference pattern;

(c) irradiating said mixture; and

(d) measuring any local deviation of a pattern characteristic of said reference pattern;

wherein said local deviation is captured in an image, further wherein said image is acquired using a photodetector, further wherein said photodetector is positioned such that it detects radiation from a source of irradiation after it has passed through said container and reference pattern, and further

wherein said radiation is transmitted by said container followed by said reference pattern.

4. A method for the determination of miscibility of a mixture of two or more liquids comprising:

(a) preparing said mixture in a container, wherein the shape of said container causes convergence or divergence of transmitted radiation;

(b) placing said container in proximity to a reference pattern;

(c) irradiating said mixture; and

(d) measuring any local deviation of a pattern characteristic of said reference pattern;

wherein said local deviation is captured in an image, further wherein said image is acquired using a photodetector, further wherein said photodetector is positioned such that it detects radiation from a source of irradiation after it has passed through said container and reference pattern, and further

wherein said radiation is reflected after passing through said container and reference pattern.

5. A method for the determination of miscibility of a mixture of two or more liquids comprising:

(a) preparing said mixture in a container, wherein the shape of said container causes convergence or divergence of transmitted radiation;

(b) placing said container in proximity to a reference pattern;

(c) irradiating said mixture; and

(d) measuring any local deviation of a pattern characteristic of said reference pattern;

wherein said local deviation is captured in an image, further wherein said image is acquired using a photodetector, further wherein said photodetector is positioned such that it detects radiation from a source of irradiation after it has passed through said container and reference pattern, and further

wherein said radiation is reflected after transmission through said reference pattern followed by said container.

6. A method for the determination of miscibility of a mixture of two or more liquids comprising:

(a) preparing said mixture in a container, wherein the shape of said container causes convergence or divergence of transmitted radiation;

(b) placing said container in proximity to a reference pattern;

(c) irradiating said mixture; and

(d) measuring any local deviation of a pattern characteristic of said reference pattern;

wherein said local deviation is captured in an image, further wherein said image is acquired using a photodetector, further wherein said photodetector is positioned such that it detects radiation from a source of irradiation after it has passed through said container and reference pattern, and further

wherein said radiation is reflected after transmission through said container followed by said reference pattern.

7. A method for the determination of miscibility of a mixture of two or more liquids comprising:

(a) preparing said mixture in a container, wherein the shape of said container causes convergence or divergence of transmitted radiation;

(b) placing said container in proximity to a reference pattern;

(c) irradiating said mixture; and

(d) measuring any local deviation of a pattern characteristic of said reference pattern;

wherein said reference pattern is opaque and a substrate for said reference pattern is substantially transparent.

8. A method for the determination of miscibility of a mixture of two or more liquids comprising:

(a) preparing said mixture in a container, wherein the shape of said container causes convergence or divergence of transmitted radiation;

(b) placing said container in proximity to a reference pattern;

(c) irradiating said mixture; and

(d) measuring any local deviation of a pattern characteristic of said reference pattern;

wherein said reference pattern is reflective and is mounted on a nonreflective or less reflective substrate.

9. A method for the determination of miscibility of a mixture of two or more liquids comprising:

(a) preparing said mixture in a container, wherein the shape of said container causes convergence or divergence of transmitted radiation;

(b) placing said container in proximity to a reference pattern;

(c) irradiating said mixture; and

(d) measuring any local deviation of a pattern characteristic of said reference pattern;

wherein said reference pattern is nonreflective and is mounted on a reflective or more reflective substrate.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 28, 2005
From: MOORE, CHRISTOPHER; SHIMIZU, KENTARO; KANE, NATHAN; GONZALEZ-ZUGASTI, JAVIER
To: TRANSFORM PHARMACEUTICALS, INC.
Reel/Frame 015798/0960 →
Continuity (3)
Provisional Application 6054658500 · Feb 20, 2004
Provisional Application 6061285000 · Sep 24, 2004
Related Publication 20050185184A1 · Aug 25, 2005