Use of rotigotine for treatment or prevention of dopaminergic neuron loss
The present patent application relates to the use of Rotigotine or its salts and prodrugs for preparation of a drug for treatment or prophylaxis of dopaminergic cell loss due to diseases that are connected with an increased dopaminergic cell loss. In particular, the patent application is related to the use of Rotigotine as a drug for preventive treatment of Morbus Parkinson.
1 - 14 . (canceled)
15 . A method for treatment or prophylaxis of dopaminergic cell loss in a subject suffering from or susceptible to a disease associated with increased dopaminergic cell loss, comprising administration of rotigotine, or a salt or prodrug thereof to the subject.
16 . The method of claim 15 , wherein the dopaminergic cell loss is associated with Morbus Parkinson.
17 . The method of claim 15 , wherein prophylactic treatment is administered to a subject selected from the group consisting of:
(a) an individual not exhibiting symptoms of Morbus Parkinson, but having a high risk for developing Morbus Parkinson; and
(b) an individual exhibiting early symptoms of Morbus Parkinson, in whom at least three of four cardinal symptoms of Morbus Parkinson are not yet present or only partially present, said symptoms being selected from the group consisting of rigor, resting tremors, bradykinesia and postural instability.
18 . The method of claim 15 , wherein the subject has one or more clinical symptoms selected from the group consisting of smell disorder, depression, sleep disorder, REM Sleep Behavior Disorders, constipation and short duration movement anomalies.
19 . The method of claim 15 , wherein the subject exhibits a mutation in a PARK-gene and/or alterations in the alpha-synuclein or neuromelanin pattern.
20 . The method of claim 15 , wherein the subject shows a loss of 60% of dopaminergic cells in the substantia nigra prior to administration of the rotigotine, or a salt or prodrug thereof.
21 . The method of claim 15 , wherein the subject has a UPDRS score of less than 9 prior to administration of the rotigotine, or salt or prodrug thereof.
22 . The method of claim 15 , wherein the subject has a Höhn-Yahr score of 0 or 1.
23 . The method of claim 15 , wherein the rotigotine, or salt or prodrug thereof, is administered by parenteral, transdermal or mucosal administration.
24 . The method of claim 15 , wherein the rotigotine, or salt or prodrug thereof, is administered at a dose of 0.05 to 50 mg per day.
25 . The method of claim 15 , wherein the prodrug is selected from the group of esters consisting of carbamates, acetals, ketals, phosphates, phosphonates, sulfates, sulfonates and silylethers.
26 . The method of claim 15 , wherein the prodrug is selected from the group of carbonates consisting of, acyloxyalkyl ethers, thiocarbonyl esters, oxythiocarbonyl esters, thiocarbamates and ethers.
27 . The method of claim 15 , wherein rotigotine or salt thereof is administered to the subject.
28 . The method of claim 15 , wherein a rotigotine prodrug is administered to the subject.
29 . A kit for diagnosis and preventive therapy of Morbus Parkinson comprising:
(a) a diagnostic agent that can enable diagnosis of Morbus Parkinson or of the predisposition to develop the Morbus Parkinson disease in the early or asymptomatic stage and
(b) a pharmaceutical formulation comprising rotigotine or a salt or prodrug thereof.
30 . A kit according to claim 29 , wherein the diagnostic agent (a) is selected from:
(i) an agent or a diagnosis kit for detection of neuromelanin;
(ii) an agent or a diagnosis kit for detection semaphorin 3;
(iii) an agent or a diagnosis kit for detection alpha-synuclein and/or its aggregates; or
(iv) an agent or a diagnosis kit for genetic evidence of the mutations connected with the occurrence of Morbus Parkinson and/or with an allele associated with the frequent occurrence of Morbus Parkinson.