Targeted oxidative therapeutic formulation
View Patent ↗Pharmaceutical formulation, its method of preparation, and its use. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by an oxygen-containing oxidizing agent, such as ozone; a penetrating solvent, such as dimethyl sulfoxide; a dye containing a chelated metal, such as hematoporphyrin; and an aromatic redox compound, such as benzoquinone. The pharmaceutical formulation is used to treat horses infected with Sarcocystis protozoal infections.
1. A method for treating a protozoa-infected animal comprising:
administering to the protozoa-infected animal an effective amount of a pharmaceutical formulation comprising:
peroxidic species or reaction products resulting from oxidation of an isoprenoid by an oxygen-containing oxidizing agent, wherein the isoprenoid has less than about 35 carbons;
a penetrating solvent;
a dye containing a chelated divalent or trivalent metal; and
an aromatic redox compound.
2. The method of claim 1 , wherein the isoprenoid is in a liquid form, in a solution, or in dispersion.
3. The method of claim 1 , wherein the isoprenoid comprises ∀-terpineol, citronellol, nerol, phytol, perillyl alcohol, menthol, or famesol.
4. The method of claim 1 , wherein the isoprenoid comprises geraniol, geranylgeraniol, myricene, citrillene, citral, pinene, limonene, or linalool.
5. The method of claim 1 , wherein the oxygen-containing oxidizing agent comprises singlet oxygen, oxygen in its triplet state, superoxide anion, periodate, hydroxyl radical, peroxide, or oxygen bound to a transition element.
6. The method of claim 1 , wherein the oxygen-containing oxidizing agent comprises ozone.
7. The method of claim 1 , wherein the penetrating solvent is a liquid, micelle membrane, emollient, plasma, or vapor.
8. The method of claim 1 , wherein the penetrating solvent is dimethylsulfoxide.
9. The method of claim 1 , wherein the penetrating solvent is polyvinylpyrrolidine or a pH-buffered saline.
10. The method of claim 1 , wherein the penetrating solvent is aqueous solution, fats, sterols, lecithins, phosphatides, ethanol, propylene glycol, or methylsulfonylmethane.
11. The method of claim 1 , wherein the dye comprises porphyrin or rose bengal.
12. The method of claim 1 , wherein the dye comprises chiorophyllin, hemin, corrins, texaphrin, methylene blue, hematoxylin, eosin, erythrosin, lactoflavin, anthracene dye, hypericin, methyicholanthrene, neutral red, or fluorescein.
13. The method of claim 1 , wherein the metal comprises iron.
14. The method of claim 1 , wherein the metal comprises copper, manganese, tin, magnesium, or strontium.
15. The method of claim 1 , wherein the aromatic redox compound comprises benzoquinone or naphthoquinone.
16. The method of claim 1 further comprising an electron donor.
17. The method of claim 16 , wherein the electron donor comprises ascorbic acid or a pharmaceutical salt thereof.
18. The method of claim 16 , wherein the electron donor comprises plasma, electrical current or germanium sesquioxide.