IP Library Patent Application 11075214
Patent Application
App. No. 11/075,214

Methods and compositions for inhibiting monoamine oxidase and catechol-o-methyltransferase

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Patent No.
US None
App. No.
11/075,214
Abstract

The present invention relates to methods and compositions for inhibiting Monoamine Oxidase and/or Catechol-O-Methyltransferase in living organisms. More particularly, the present invention relates to methods and compositions involving the inhibition of Monoamine Oxidase and/or Catechol-O-Methyltransferase using processed Morinda citrifolia L. plant products.

Claims (21)

1 . A formulation adapted to inhibit Monoamine Oxidase comprising: at least one processed Morinda citrifolia product present in an amount by weight between about 0.1 and 99 percent.

2 . The formulation of claim 1 , wherein said Morinda citrifolia product is used with a carrier medium.

3 . The formulation of claim 1 , wherein said processed Morinda citrifolia product comprises a processed Morinda citrifolia product selected from a group comprising: extract from the leaves of Morinda citrifolia, leaf hot water extract present in an amount by weight between about 0.1 and 50 percent, processed Morinda citrifolia leaf ethanol extract present in an amount by weight between about 0.1 and 50 percent, processed Morinda citrifolia leaf steam distillation extract present in an amount by weight between about 0.1 and 50 percent, Morinda citrifolia fruit juice, Morinda citrifolia extract, Morinda citrifolia dietary fiber, Morinda citrifolia puree juice, Morinda citrifolia puree, Morinda citrifolia fruit juice concentrate, Morinda citrifolia puree juice concentrate, freeze concentrated Morinda citrifolia fruit juice, and evaporated concentration of Morinda citrifolia fruit juice.

4 . The formulation of claim 1 , further comprising an active ingredient selected from a group comprising quercetin, rutin, scopoletin, octoanoic acid, potassium, vitamin C, terpenoids, alkaloids, anthraquinones, nordamnacanthal, morindone, rubiandin, B-sitosterol, carotene, vitamin A, flavone glycosides, linoleic acid, Alizarin, amino acids, acubin, L-asperuloside, caproic acid, caprylic acid, ursolic acid, and putative proxeronines.

5 . The formulation of claim 1 , wherein said formulation is administered to a patient by a method selected from a list comprising orally, intravenously, and systemically.

6 . The formulation of claim 1 , further comprising an ingredient selected from the group comprising processed Morinda citrifolia products, food supplements, dietary supplements, other fruit juices, other natural ingredients, natural flavorings, artificial flavorings, natural sweeteners, artificial sweeteners, natural coloring, and artificial coloring.

7 . A formulation comprising:

a Morinda citrifolia product present in an amount by weight between about 0.1 and 99 percent, wherein the formulation is adapted to inhibit Monoamine Oxidase.

8 . A method to inhibit Monoamine Oxidase in mammals comprising the step of:

administering a formulation containing at least one processed Morinda citrifolia product present in an amount by weight between about 0.1 and 99 percent.

9 . The method of claim 8 , wherein two ounces of the formulation is administered twice daily.

10 . The method of claim 8 , wherein said Morinda citrifolia product is administered with a carrier medium.

11 . The method of claim 8 , wherein said processed Morinda citrifolia product comprises a processed Morinda citrifolia selected from a group consisting of: extract from the leaves of Morinda citrifolia, leaf hot water extract present in an amount by weight between about 0.1 and 50 percent, processed Morinda citrifolia leaf ethanol extract present in an amount by weight between about 0.1 and 50 percent, processed Morinda citrifolia leaf steam distillation extract present in an amount by weight between about 0.1 and 50 percent, Morinda citrifolia fruit juice, Morinda citrifolia extract, Morinda citrifolia dietary fiber, Morinda citrifolia puree juice, Morinda citrifolia puree, Morinda citrifolia fruit juice concentrate, Morinda citrifolia puree juice concentrate, freeze concentrated Morinda citrifolia fruit juice, and evaporated concentration of Morinda citrifolia fruit juice.

12 . The method of claim 8 , wherein the formulation comprises at least one active ingredient selected from a group consisting of quercetin, rutin, scopoletin, octoanoic acid, potassium, vitamin C, terpenoids, alkaloids, anthraquinones, nordamnacanthal, morindone, rubiandin, B-sitosterol, carotene, vitamin A, flavone glycosides, linoleic acid, Alizarin, amino acids, acubin, L-asperuloside, caproic acid, caprylic acid, ursolic acid, and putative proxeronines.

13 . The method of claim 8 , wherein the formulation further comprising at least one other ingredient selected from the group consisting of processed Morinda citrifolia products, food supplements, dietary supplements, other fruit juices, other natural ingredients, natural flavorings, artificial flavorings, natural sweeteners, artificial sweeteners, natural coloring, and artificial coloring.

14 . The method of claim 8 , further comprising the step of concurrently administering said formulation with another medication designed to improve monoamine oxidase activity and its associated conditions, wherein said formulation increases the efficacy of said medication.

15 . The method of claim 8 , wherein said formulation is administered in an amount between about 1 teaspoon and 2 ounces at least twice daily on an empty stomach each day.

16 . A method of treating mammals comprising:

administering a formulation containing a processed Morinda citrifolia product present in an amount by weight between about 0.1 and 99 percent, wherein the formulation is adapted to affect a mammal in a way selected from a list consisting of: inhibiting Monoamine Oxidase, preventing a complication of a primary disorder in patients wherein said complication results from Monoamine Oxidase activity, treating a primary disorder in patients wherein said disorder results from Monoamine Oxidase activity, preventing a primary disorder in patients wherein said disorder results from Monoamine Oxidase activity, inhibiting Catechol-O-Methyltransferase, treating neurological disorders, preventing neurological disorders, treating schizophrenia, preventing schizophrenia, treating Alzheimer's, preventing Alzheimer's, treating Parkinson's, preventing Parkinson's, treating neurodegenerative disorders, preventing neurodegenerative disorders, treating depression, and preventing depression.

17 . A formulation for treating mammals comprising:

a processed Morinda citrifolia product present in an amount by weight between about 0.1 and 99 percent, wherein the formulation is adapted to affect a mammal in a way selected from a list consisting of: inhibiting Monoamine Oxidase, preventing a complication of a primary disorder in patients wherein said complication results from Monoamine Oxidase activity, treating a primary disorder in patients wherein said disorder results from Monoamine Oxidase activity, preventing a primary disorder in patients wherein said disorder results from Monoamine Oxidase activity, inhibiting Catechol-O-Methyltransferase, treating neurological disorders, preventing neurological disorders, treating schizophrenia, preventing schizophrenia, treating Alzheimer's, preventing Alzheimer's, treating Parkinson's, preventing Parkinson's, treating neurodegenerative disorders, preventing neurodegenerative disorders, treating depression, and preventing depression.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 5, 2007
From: MORINDA, INC.
To: TAHITIAN NONI INTERNATIONAL, INC.
Reel/Frame 018851/0222 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 25, 2005
From: PALU, AFA KEHAATI; ZHOU, BING NAN; JENSEN, CLAUDE JARAKAE; STORY, STEPHEN
To: MORINDA, INC.
Reel/Frame 016060/0802 →