IP Library Granted Patent US 7,749,171
Granted Patent B2
US 7,749,171 · App. 11/076,789 · Granted Jul 6, 2010

Method for automated detection of A-waves

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Quick Facts
Patent No.
US 7,749,171
App. No.
11/076,789
Granted
Jul 6, 2010
Kind
B2
Abstract

In one form of the present invention, there is provided a method for detecting an A-wave, the method comprising: applying a series of stimuli to a nerve; recording a series of late responses; creation of a feature space map from an ensemble of late responses; identification of clusters within the feature space that represent A-wave components; consolidation of A-wave components into a discrete collection of A-waves; removal of false positive A-waves; and extraction of A-wave characteristics. In another form of the present invention, there is provided a system for detecting an A-wave comprising: a stimulation electrode; a stimulation circuit connected to the stimulation electrode for applying a series of stimuli to a nerve; a detection electrode; a detection circuit connected to the detection electrode; and an analyzer connected to the detection electrode and adapted to detect an A-wave by: recording a series of late responses detected by the detection circuit; creation of a feature space map from an ensemble of late responses; identification of clusters within the feature space map that represent A-wave components; consolidation of A-wave components into a discrete collection of A-waves; removal of false positive A-waves; and extraction of A-wave characteristics.

Claims (17)

1. A method for detecting an A-wave, the method comprising:

applying a series of stimuli to a nerve;

recording a series of evoked bioelectrical responses;

identifying one or more attributes in each of the responses;

utilizing each of the one or more attributes of each of the responses to create a new data set;

creating a search window that is smaller than the new data set;

searching the new data set for trends by:

sequentially applying the search window across the new data set; and

analyzing the search window by counting the number of data points contained within the search window at each separate, sequential search window position;

analyzing the new data set by:

registering a positive for an A-wave component if the number of data points contained within the search window at each separate, sequential search window position exceeds a predetermined threshold; and

registering a negative for an A-wave component if the number of data points contained within the search window at each separate, sequential search window position does not exceed a predetermined threshold; and

consolidating the A-wave components into a single A-wave.

2. A method according to claim 1 wherein the search window has an area such that the height of the search window is proportional to the amplitude location within the new data set.

3. A method according to claim 1 wherein the one or more attributes comprise the amplitude of local maxima and/or local minima.

4. A method according to claim 1 wherein the one or more attributes comprise the absolute value amplitude.

5. A method according to claim 1 wherein the one or more attributes comprise the second derivative of amplitude.

Assignments (2)
SECURITY INTEREST Recorded Aug 12, 2025
From: NEUROMETRIX, INC.
To: AVENUE VENTURE OPPORTUNITIES FUND II, L.P.
Reel/Frame 072450/0668 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 17, 2005
From: GOZANI, SHAI N.; KONG, XUAN
To: NEUROMETRIX, INC.
Reel/Frame 017093/0039 →