Method for soft tissue treatment

1. A method for non-invasive treatment of a soft tissue volume, causing destruction of fat cells, with little or no damage to other cells, said method comprising:

a) applying at least one pressure pulse to a region of skin surface overlying the soft tissue volume,

the pressure pulse having negative pressure phases and positive pressure phases with respect to ambient pressure,

with the positive pressure phases being slower than the negative pressure phases; and

b) applying a temperature effector and raising the temperature of the soft tissue volume during treatment to a temperature above 37° C. by applying RF energy to the soft tissue.

2. The method according to claim 1 , wherein at least one of the negative pressure phases has an intensity between 0.1 Bar and 10 Bars below ambient pressure.

3. The method according to claim 1 , wherein at least one of the negative pressure phases has a duration between 0.1 millisecond and 100 milliseconds.

4. The method according to claim 1 , wherein at least one of the positive pressure phases has an intensity between 1 and 30 Bars above ambient pressure.

5. The method according to claim 1 , wherein at least one of the positive pressure phases has a duration between 0.01 msec to 1 msec.

6. The method according to claim 1 , further comprising applying a matching medium coupling energy delivery from an applicator to the skin surface.

7. The method according to claim 6 , wherein the matching medium is a liquid or gel.

8. The method according to claim 1 , further comprising cooling the skin surface.