IP Library › Granted Patent US 7,960,536
Granted Patent B2
US 7,960,536 · App. 11/080,827 · Granted Jun 14, 2011

Synthetic cell-or tissue-specific transcriptional regulatory regions

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Quick Facts
Patent No.
US 7,960,536
App. No.
11/080,827
Granted
Jun 14, 2011
Kind
B2
Abstract

The invention concerns making and evaluating synthetic regulatory regions for controlling gene expression. The invention features a method for identifying transcription factor binding sites and a method for evaluating the regulatory functions of synthetic regulatory regions.

Claims (4)

1. A muscle specific promoter comprising a synthetic regulatory region comprising an arrangement of at least three different transcription factor binding sites selected from the group consisting of SRE, MEF-1, MEF-2, TEF-1, Sp1, and combinations thereof.

2. The muscle specific promoter of claim 1 , wherein the synthetic regulatory region comprises at least one copy of SRE, MEF-1, and MEF-2.

3. The muscle specific promoter of claim 2 , further comprising at least one copy of TEF1.

4. The muscle specific promoter of claim 2 , further comprising at least one copy of Sp1.

Assignments (2)
MERGER Recorded Feb 2, 2021
From: GENETRONICS, INC.
To: INOVIO PHARMACEUTICALS, INC.
Reel/Frame 055114/0784 →
NUNC PRO TUNC ASSIGNMENT Recorded Apr 1, 2010
From: URIGEN PHARMACEUTICALS, INC.
To: GENETRONICS, INC.
Reel/Frame 024172/0608 →