Local anesthetic methods and kits
Methods of reversing local anesthesia are disclosed. The methods comprise administering a local anesthetic and alpha adrenergic receptor agonist to induce local anesthesia followed by reversing anesthesia with a low dose of an alpha adrenergic receptor antagonist. Also disclosed are kits comprising a local anesthetic, an alpha adrenergic receptor agonist and a low dose of an alpha adrenergic receptor antagonist.
1 - 32 . (canceled)
33 . A solution comprising an alpha adrenergic receptor antagonist at a concentration of from about 0.001 mg/mL to about 0.25 mg/mL, wherein said solution is effective to reverse anesthesia in an animal caused by previous administration of an anesthetic agent and an alpha adrenergic receptor agonist, said solution being present in a container that fits into a standard dental local anesthetic syringe.
34 . The solution of claim 33 wherein said alpha adrenergic receptor antagonist is selected from the group consisting of phentolamine, phentolamine mesylate, phentolamine hydrochloride, tolazoline, yohimbine, rauwolscine, doxazosine, labetalol, prazosine, tetrazosine and trimazosine.
35 . The solution of claims 33 , wherein said alpha adrenergic receptor antagonist is at a concentration of about 0.05 mg/mL to about 0.25 mg/mL.
36 . The solution of claim 35 , wherein said alpha adrenergic receptor antagonist is present at a concentration of about 0.25 mg/mL.
37 . The solution of claim 33 , wherein said container comprises a dose of said alpha adrenergic receptor antagonist of between about 0.0018 mg to about 0.45 mg.
38 . The solution of claim 37 , wherein said dose is between about 0.09 mg to about 0.45 mg.
39 . The solution of claim 37 , wherein said container comprises a dose of alpha adrenergic receptor antagonist at or below about 0.25 mg.
40 . The solution of claims 33 , wherein said container is a CARPULE.
41 . The solution of claims 33 , wherein said container has a volume of between 1.6 and 1.8 mL.