IP Library › Granted Patent US 7,501,128
Granted Patent B2
US 7,501,128 · App. 11/083,175 · Granted Mar 10, 2009

IHNV G protein for immune stimulation

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Quick Facts
Patent No.
US 7,501,128
App. No.
11/083,175
Granted
Mar 10, 2009
Kind
B2
Abstract

A vaccine comprises a portion of IHNV G protein and a portion of a second protein from a fish pathogen, or their respective nucleic acid coding sequences. The presence of the IHNV G protein boosts the immune response to the second protein, resulting in a protective effect against infection by the fish pathogen and/or mortality caused by the fish pathogen from which the second protein is derived.

Claims (9)

1. A fusion protein comprising IHNV G protein including the leader sequence of the G protein and a second protein wherein said second protein is an antigen from a pathogen.

2. The fusion protein of claim 1 wherein said pathogen is selected from the group consisting of ISAV, IPNV, iridovirus, NNV, SPDV, SVCV, VHSV, koi herpesvirus, HSMI virus, Renibacterium salmoniarum, Piscirickettsia salmonis, Vibrio spp., Aeromonas spp., Yersinia ruckerii, Nocardia spp., Pseudomonas spp., and Photobacterium damselae.

3. A fusion protein comprising the amino acid sequence of SEQ ID NO: 1 and a second protein wherein said second protein is an antigen from a pathogen.

4. The fusion protein of claim 3 wherein said pathogen is selected from the group consisting of ISAV, IPNV, iridovirus, NNV, SPDV, SVCV, VHSV, koi herpesvirus, HSMI virus, Renibacterium salmoniarum, Piscirickettsia salmonis, Vibrio spp., Aeromonas spp., Yersinia ruckerii, Nocardia spp., Pseudomonas spp., and Photobacterium damselae.

5. A composition comprising a portion of the IHNV G protein and a second protein wherein said second protein is an antigen from a fish pathogen selected from the group consisting of ISAV, IPNV, iridovirus, NNV, SPDV, SVCV, VHSV, koi herpesvirus, HSMI virus, i Renibacterium salmoniarum, Piscirickettsia salmonis, Vibrio spp., Aeromonas spp., Yersinia ruckerii, Nocardia spp., Pseudomonas spp., and Photobacterium damselae ; and wherein said portion of the IHNV G protein is selected from the group consisting of the mature G protein, the leader sequence of the G protein, and the G protein with the leader sequence.

6. The fusion protein of claim 1 , wherein said second protein is IPNV VP2.

7. The fusion protein of claim 1 , wherein said second protein is ISAV hemagglutinin (HA).

8. A composition comprising the fusion protein of claim 6 .

9. A composition comprising the fusion protein of claim 7 .

Assignments (6)
ASSIGNMENT OF SECURITY INTEREST IN PATENT RIGHTS, RECORDED ON AUGUST 3, 2020, AT REEL/FRAME 053388/0967 Recorded Dec 3, 2025
From: GOLDMAN SACHS BANK USA, AS RETIRING COLLATERAL AGENT
To: JPMORGAN CHASE BANK, N.A., AS SUCCESSOR COLLATERAL AGENT
Reel/Frame 073816/0021 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 10, 2025
From: ELANCO US INC.
To: INTERVET INC.
Reel/Frame 070456/0320 →
SECURITY INTEREST Recorded Aug 3, 2020
From: ELANCO US INC.
To: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
Reel/Frame 053388/0967 →
CHANGE OF NAME Recorded Nov 2, 2015
From: NOVARTIS ANIMAL HEALTH US, INC.
To: ELANCO US INC.
Reel/Frame 037019/0739 →
CORRECT AN ERROR MADE IN A PREVIOUSLY RECORDED DOCUMENT THAT ERRONEOUSLY AFFECTS THE IDENTIFIED PATENT Recorded Apr 10, 2015
From: NOVARTIS ANIMAL HEALTH US, INC.
To: NOVARTIS ANIMAL HEALTH US, INC.
Reel/Frame 035399/0244 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 10, 2015
From: NOVARTIS AG
To: NOVARTIS TIERGESUNDHEIT AG
Reel/Frame 034926/0390 →