Tissue products derived from porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
View Patent ↗The present invention provides tissues derived from animals, which lack any expression of functional alpha 1,3 galactosyltransferase (alpha-1,3-GT). Such tissues can be used in the field of xenotransplantation, such as orthopedic reconstruction and repair, skin repair and internal tissue repair or as medical devices.
1. A tissue product, comprising a tissue stripped of viable cells wherein the tissue is derived from a tissue of a porcine animal in which at least one allele of an α-1,3-galactosyltransferase gene is inactivated and wherein the animal lacks expression of alpha-1,3-galactosyltransferase.
2. The tissue product of claim 1 , wherein the tissue stripped of viable cells is produced by enzymatic treatment.
3. The tissue product of claim 1 , wherein the tissue is bone.
4. The tissue product of claim 1 , wherein the tissue stripped of viable cells is produced by chemical treatment.
5. The tissue product of claim 1 , wherein the tissue is selected from the group consisting of tendon, joint, bone and heart valve.
6. The tissue product of claim 2 or 4 , wherein the tissue can be further processed via crosslinking treatments.
7. The tissue product of claim 2 or 4 , wherein the tissue can be further processed via additional chemical treatments.