Process for preparing secondary alcohol
View Patent ↗A process for preparing a secondary alcohol which is characterized in adding a primary or a secondary amine in the reaction system in case that the secondary alcohol is prepared by hydrogenating in the presence of a noble metal, an epoxy derivative represented by the following formula, wherein R 1 and R 2 are the same or different, an organic group not containing aldehyde group or ketone group therein or hydrogen atom, provided that both R 1 and R 2 are not simultaneously hydrogen atom.
1. A process for preparing a secondary alcohol represented by formula (2a),
wherein R 1a is optionally unsaturated C1–10 alkyl group, halogeno C1–10 alkyl group, optionally unsaturated C3–10 cycloalkyl group, aralkyl group, hydroxy substituted C1–10 alkyl group, C1–10 alkyloxy substituted C1–10 alkyl group, furyl substituted C1–10 alkyl group, or aryloxy substituted C1–10 alkyl group, and R 2a is hydrogen atom, which comprises reacting a primary amine or a secondary amine, a noble metal catalyst and an epoxy derivative represented by formula (1a),
wherein R 1a and R 2a are the same as defined above, to obtain the secondary alcohol represented by formula (2a).
2. The process for preparing a secondary alcohol according to claim 1 wherein R 1a is C1–10 alkyl and R 2a is hydrogen atom.
3. The process for preparing a secondary alcohol according to claim 1 wherein the epoxy derivative (1a) is an optically active compound.
4. The process for preparing a secondary alcohol according to claim 1 wherein the noble metal catalyst is palladium.
5. The process for preparing a secondary alcohol according to claim 2 wherein the noble metal catalyst is palladium.
6. The process for preparing a secondary alcohol according to claim 3 wherein the noble metal catalyst is palladium.
7. The process for preparing a secondary alcohol according to claim 4 wherein the epoxy derivative (1a) is 1,2-epoxybutane, 1,2-epoxypentane, 1,2-epoxyhexane or 1,2-epoxyoctane.
8. The process for preparing a secondary alcohol according to claim 5 wherein the epoxy derivative (1a) is 1,2-epoxybutane, 1,2-epoxypentane, 1,2-epoxyhexane or 1,2-epoxyoctane.
9. The process for preparing a secondary alcohol according to claim 6 wherein the epoxy derivative (1a) is 1,2-epoxybutane, 1,2-epoxypentane, 1,2-epoxyhexane or 1,2-epoxyoctane.
10. The process for preparing a secondary alcohol according to claim 1 wherein the secondary alcohol (2a) is an optically active compound.