Biologic replacement for fibrin clot

1. A scaffold for repair of an intra-articular tissue defect in an intrasynovial environment comprising a three-dimensional matrix designed to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient's joint at the site of the intra-articular tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, and wherein said scaffold further comprises plasma.

2. A scaffold for repair of an intra-articular tissue defect in an intrasynovial environment comprising a three-dimensional matrix designed to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient's joint at the site of the intra-articular tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, and wherein said scaffold further comprises a platelet.

3. A scaffold for repair of an intra-articular tissue defect in an intrasynovial environment comprising a three-dimensional matrix designed to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient's joint at the site of the intra-articular tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, and wherein said scaffold further comprises a neutralizing agent.

4. A scaffold for repair of an intra-articular tissue defect in an intrasynovial environment comprising a three-dimensional matrix designed to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient's joint at the site of the intra-articular tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, wherein said scaffold further comprises plasma, a platelet or a neutralizing agent, and wherein said intra-articular tissue defect is of labrum.

5. The scaffold as in any one of claims 1 , 2 , 3 , or 4 , wherein the scaffold is resistant to degradation by synovial fluid.

6. The scaffold as in any one of claims 1 , 2 , 3 , or 4 , wherein said matrix is freeze dried.

7. The scaffold as in any one of claims 1 , 2 , 3 , or 4 , further comprising a glycosaminoglycan.

8. The scaffold as in any one of claims 1 , 2 , 3 , or 4 , further comprising a growth factor.

9. The scaffold of claim 8 , wherein the growth factor is selected from the group consisting of: epidermal growth factor (EGF); fibroblast growth factor (FGF); transforming growth factor (TGF); and platelet derived growth factor (PDGF).

10. The scaffold as in any one of claims 1 , 2 , 3 , or 4 , further comprising a cytokine.

11. The scaffold as in any one of claims 2 , 3 , or 4 , further comprising plasma.

12. The scaffold as in any one of claims 1 , 3 , or 4 , further comprising a platelet.

13. The scaffold as in any one of claims 1 , 2 , or 4 , further comprising a neutralizing agent.

14. The scaffold as in any one of claims 1 , 2 , 3 , or 4 , further comprising an extracellular matrix protein.

15. The scaffold of claim 14 , wherein the extracellular matrix protein is selected from the group consisting of elastin, laminin, fibronectin and entectin.

16. The scaffold as in any one of claim 1 , 2 , or 3 , wherein said intra-articular tissue defect is a partial or complete tear of a ligament exposed to synovial fluid, and wherein the ligament is an anterior cruciate ligament (ACL).

17. The scaffold as in any one of claim 1 , 2 , 3 , or 4 , wherein the intra-articular tissue defect is of the meniscus.

18. The scaffold as in any one of claim 1 , 2 , 3 , or 4 , wherein the intra-articular tissue defect is of cartilage.

19. The scaffold as in any one of claims 1 , 2 , 3 , wherein the intra-articular tissue defect is of labrum.

20. The scaffold as in any one of claims 1 , 2 , 3 , wherein the intra-articular tissue defect is of bone.

21. The scaffold as in any one of claims 1 , 2 , 3 , or 4 , further comprising a suture or clip.

22. The scaffold as in any one of claims 1 , 2 , 3 , or 4 , wherein the scaffold is cross-linked with a crosslinking agent.

23. The scaffold of claim 22 , wherein the crosslinking agent is selected from the group consisting of a gluteraldehyde, ethanol, ultraviolet light, and a dehydrothermal agent.