IP Library › Granted Patent US 7,291,743
Granted Patent B2
US 7,291,743 · App. 11/093,182 · Granted Nov 6, 2007

Isoxazole derivatives and methods of treating nitric oxide mediated diseases

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Quick Facts
Patent No.
US 7,291,743
App. No.
11/093,182
Granted
Nov 6, 2007
Kind
B2
Abstract

A series of isoxazole derivatives and methods of suppressing, inhibiting, or preventing disorders mediated by nitric oxide (NO) and/or proinflammatory cytokines, such as TNF-α (tumor necrosis factor alpha), IL-1 (interlukin-1), and IL-6, are described.

Claims (5)

1. A compound of formula (I):

or a physiological tolerable salt thereof;

wherein R is

wherein R1 is selected from the group consisting of

wherein R2 is lower alkyl or substituted lower alkyl.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 23, 2007
From: UNITECH PHARMACEUTICALS, INC.
To: GENEBLUE CORPORATION
Reel/Frame 019733/0564 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 27, 2005
From: SHAW, JIAJIU; LEE, AN-RONG; HUANG, WEN-HSIN
To: UNITECH PHARMACEUTICALS, INC.
Reel/Frame 016425/0881 →