Aryl aniline β
View Patent ↗The invention provides novel β 2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β 2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.
1. A compound of formula (V):
wherein:
R 1 is methoxy or ethoxy, and R 2 is hydrogen or phenyl; or R 1 is hydrogen, and R 2 is phenyl;
R 3 is —CH 2 OH or —NHCHO, and R 4 is hydrogen; or R 3 and R 4 taken together are —NHC(═O)CH═CH—;
R a is hydrogen or an amino-protecting group; and
R b is a hydroxy-protecting group.
2. The compound of claim 1 wherein R a is hydrogen.
3. The compound of claim 2 wherein R b is benzyl.
4. The compound of claim 1 wherein R a is benzyl and R b is benzyl.
5. The compound of claim 1 wherein R 3 is CH 2 OH.
6. The compound of claim 1 wherein R 3 is NHCHO.
7. The compound of claim 1 wherein R 1 is ethoxy and R 2 is phenyl.
8. The compound of claim 1 wherein R 3 and R 4 taken together are —NHC(═O)CH═CH—.
9. The compound of claim 8 wherein R 1 is methoxy and R 2 is phenyl.
10. The compound of claim 9 wherein R a is benzyl and R b is benzyl.
11. The compound of claim 9 wherein R a is hydrogen and R b is benzyl.
12. The compound of claim 1 having the chemical structure: