Medical devices having soft, flexible lubricious coatings
View Patent ↗Soft, flexible highly lubricious coatings for polymeric IOL insertion cartridges that allow IOLs to be easily inserted through small bore cartridges suitable for use with small (less than 3 mm) incisions are provided. These lubricious coatings allow IOLs to be inserted into the eye of a patient without the risk of lens damage or transfer of lubricants to the lens surface during implantation. Specifically, polymeric coatings comprising a matrix polymer having an equivalent weight greater than 5000 g/eq are used to form interpenetrating networks (IPN) on the surface of hydrophobic structural polymers. The IPNs thus formed entrap highly lubricious hydrophilic compounds within the IPN using multi-functional cross linkers.
1. An intraocular lens (IOL) inserter cartridge comprising:
a soft lubricious coating comprising a urethane matrix polymer, wherein the urethane matrix polymer comprises urethane having an equivalent weight between 10,000 g/eq and 15,000 g/eq;
a hydrophilic lubricious lubricant; and
a multi-functional cross-linker.
2. The intraocular lens (IOL) inserter cartridge according to claim 1 wherein said hydrophilic lubricious lubricant is selected from the group consisting of polyvinylpyrrolidone, polyethylene oxide and hyaluronic acid.
3. The intraocular lens (IOL) inserter cartridge according to claim 2 wherein the hydrophilic lubricious lubricant is polyvinylpyrrolidone.
4. The intraocular lens (IOL) inserter cartridge according to claim 1 wherein said multi-functional cross-linker is aziridine.
5. The intraocular lens (IOL) inserter cartridge according to claim 1 wherein said urethane has an equivalent weight between 10,000 g/eq and 12,000 g/eq.
6. The intraocular lens (IOL) inserter cartridge according to claim 1 wherein said urethane has an equivalent weight of 11,688 g/eq.
7. The intraocular lens (IOL) inserter cartridge according to claim 1 further comprising at least one performance enhancing composition selected from the group consisting of ultraviolet light absorbers, anti-foam reagents, de-foaming reagents, wetting solutions, detergents, emulsifiers, preservatives, anti-thrombogenic compounds, anti-coagulants, anti-inflammatories, cytostatic compounds, cytotoxic compounds, antibiotics, and analgesics.
8. An intraocular lens (IOL) inserter cartridge comprising:
a soft, lubricious coating comprising a urethane matrix polymer, wherein the urethane matrix polymer comprises urethane having an equivalent weight of between 10,000 g/eq and 12,000 g/eq;
a hydrophilic lubricious lubricant comprising polyvinylpyrrolidone; and
a multi-functional cross-linker comprising poly-functional aziridine.
9. The intraocular lens (IOL) inserter cartridge according to claim 8 wherein said urethane has an equivalent weight of 11,688 g/eq.
10. The intraocular lens (IOL) inserter cartridge according to claim 8 further comprising a least one performance enhancing composition selected from the group consisting of ultraviolet light absorbers, anti-foam reagents, de-foaming reagents, wetting solutions, detergents, emulsifiers, preservatives, anti-thrombogenic compounds, anti-coagulants, anti-inflammatories, cytostatic compounds, cytotoxic compounds, antibiotics, and analgesics.
11. An IOL inserter cartridge having a soft coating consisting essentially of:
a urethane matrix polymer, wherein the urethane matrix polymer comprises urethane having an equivalent weight of between 10,000 g/eq and 12,000 g/eq;
a hydrophilic lubricious lubricant consisting essentially of polyvinylpyrrolidone; and
a multi-functional cross-liner consisting essentially of poly-functional aziridine.
12. The IOL inserter cartridge according to claim 11 , wherein said urethane has an equivalent weight of 11,688 g/eq.
13. An IOL inserter having a soft coating consisting essentially of:
a urethane matrix polymer, wherein the urethane matrix polymer comprises urethane having an equivalent weight of 11,688 g/eq;
a hydrophilic lubricious lubricant consisting essentially of polyvinylpyrrolidone; and
a multi-functional cross-liner consisting essentially of poly-functional aziridine.
14. The IOL inserter cartridge according to claim 13 further comprising at least one performance enhancing composition selected from the group consisting of ultraviolet light absorbers, anti-foam reagents, de-foaming reagents, wetting solutions, detergents, emulsifiers, preservatives, anti-thrombogenic compounds, anti-coagulants, anti-inflammatories, cytostatic compounds, cytotoxic compounds, antibiotics, and analgesics.
15. The IOL inserter cartridge according to any one of claims 8 , 11 and 13 wherein said urethane matrix polymer of said soft lubricious coating has a glass transition temperature below −50° C.