Antigenic neisserial peptides
WO99/24578 discloses a large number of proteins from Neisseria meningitidis and Neisseria gonorrhoeae . The present invention relates to fragments of those proteins which comprise at least one antigenic determinant. Homologous sequences and proteins comprising these fragments are also disclosed.
1 . A fragment of a protein disclosed in WO99/24578, wherein the fragment comprises at least one antigenic determinant.
2 . The fragment of claim 1 , having a length of 100 amino acids or less.
3 . The fragment of claim 1 having a length of 3 amino acids or greater.
4 . The fragment of claim 1 , being one of the 14151 fragments of Table 1.
5 . A polypeptide having 50% or greater sequence identity to the fragment of any preceding claim.
6 . A protein comprising one or more fragment of claim 1 , claim 2 or claim 3 , with the proviso that the protein is not one of the 446 complete protein sequences disclosed in WO99/24578.
7 . An antibody which recognises the fragment according to claim 1 .
8 . A protein comprising a peptide sequence, wherein the peptide sequence is recognised by an antibody according to claim 7 .
9 . Nucleic acid encoding the fragment of claim 1 , claim 2 or claim 3 .
10 . A composition comprising the fragment of claim 1 , claim 2 or claim 3 .
11 . (canceled)
12 . (canceled)
13 . A method of treating a patient, comprising administering to the patient a therapeutically effective amount of a composition according to claim 10 .
14 . The fragment of claim 2 , having a length of 3 amino acids or greater.
15 . Nucleic acid encoding the polypeptide of claim 5 .
16 . Nucleic acid encoding the protein of claim 8 .
17 . A composition comprising the antibody of claim 7 .
18 . A composition comprising the nucleic acid of claim 9 .
19 . A method for treating a patient, comprising administering to the patient a therapeutically effective amount of a composition according to claim 17 .
20 . A method for treating a patient, comprising administering to the patient a therapeutically effective amount of a composition according to claim 18.