Method of implanting a sterile, active agent-coated material and composition made according to same
The present invention relates to a method of implanting a sterile, active agent-coated material comprising contacting a sterile implant with a sterile active agent or active agent solution to form a sterile, active agent-coated implant and, at most a relatively short time after forming the active agent-loaded sterile implant, implanting the active agent-loaded sterile implant into a subject such as a mammal or a human.
1 . A method of forming a sterile active agent-loaded implant comprising:
providing a sterile implant having a surface that is capable of associating with an active agent;
providing a sterile composition comprising an active agent; and
contacting the sterile implant surface with the sterile active agent-containing composition, so that the sterile implant at least partially physically associates, at least partially chemically associates, or both, with the active agent to form an active agent-loaded sterile implant.
2 . The method of claim 1 , wherein the sterile active agent-containing composition comprises a carrier for the active agent, a solvent for the active agent, or both.
3 . The method of claim 2 , wherein the solvent comprises water.
4 . The method of claim 2 , wherein the active agent comprises an antibacterial agent, an antiviral agent, an osseointegrative, osteoconductive, and/or osteoinductive agent, a mitogenic growth factor, a morphogenic growth factor, an osteoclast inhibitor, an antiinflammatory agent, or a combination thereof.
5 . The method of claim 1 , wherein the sterile implant comprises a coating layer, which layer comprises hyaluronic acid, a hyaluronate salt, a (co)polymer containing alkylene oxide repeat units, or a combination thereof.
6 . The method of claim 4 , wherein the sterile implant comprises a coating layer, which layer comprises hyaluronic acid, a hyaluronate salt, a (co)polymer containing alkylene oxide repeat units, or a combination thereof.
7 . The method of claim 3 , wherein the sterile implant comprises a coating layer, which layer comprises a hydrophilic (co)polymer, a water-swellable (co)polymer, or both.
8 . The method of claim 1 , wherein providing the sterile implant comprises sterilization through exposure to heat, radiation, chemical treatment, or a combination thereof.
9 . The method of claim 1 , wherein providing the sterile active agent-containing composition comprises sterilization through exposure to heat, filtration through a sub-micron filter, or a combination thereof.
10 . The method of claim 3 , wherein providing the sterile active agent-containing composition comprises sterilization through exposure to heat, filtration through a sub-micron filter, or a combination thereof.
11 . A method of implanting a sterile active agent-coated material, a sterile active agent-coated device, or both, comprising:
performing the method according to claim 1 to form an active agent-loaded sterile implant; and
within about 3 hours after forming the active agent-loaded sterile implant, implanting the active agent-loaded sterile implant into a subject.
12 . The method of claim 11 , wherein the sterile active agent-containing composition comprises a carrier for the active agent, a solvent for the active agent, or both.
13 . The method of claim 12 , wherein the solvent comprises water.
14 . The method of claim 12 , wherein the active agent comprises an antibacterial agent, an antiviral agent, an osseointegrative, osteoconductive, and/or osteoinductive agent, a mitogenic growth factor, a morphogenic growth factor, an osteoclast inhibitor, an antiinflammatory agent, or a combination thereof.
15 . The method of claim 11 , wherein the sterile implant comprises a coating layer, which layer comprises hyaluronic acid, a hyaluronate salt, a (co)polymer containing alkylene oxide repeat units, or a combination thereof.
16 . The method of claim 14 , wherein the sterile implant comprises a coating layer, which layer comprises hyaluronic acid, a hyaluronate salt, a (co)polymer containing alkylene oxide repeat units, or a combination thereof.
17 . The method of claim 13 , wherein the sterile implant comprises a coating layer, which layer comprises a hydrophilic (co)polymer, a water-swellable (co)polymer, or both.
18 . The method of claim 11 , wherein providing the sterile implant comprises sterilization through exposure to heat, radiation, chemical treatment, or a combination thereof.
19 . The method of claim 11 , wherein providing the sterile active agent-containing composition comprises sterilization through exposure to heat, filtration through a sub-micron filter, or a combination thereof.
20 . The method of claim 13 , wherein providing the sterile active agent-containing composition comprises sterilization through exposure to heat, filtration through a sub-micron filter, or a combination thereof.