PIF tetrapeptides
View Patent ↗Peptides and peptidomimetics capable of enhance endometrial receptivity, blocking activated but not basal immunity, inhibiting cell proliferation and creating a T H 2 type cytokine bias are disclosed. The peptides and mimetics are based upon the C-terminal tetrapeptide of PIF peptides. Also disclosed are methods of using these peptides and peptidomimetics for therapeutic and diagnostic purposes.
1. A synthetic polypeptide consisting of P-G-S-A (SEQ ID NO:19).
2. A composition comprising:
a synthetic polypeptide consisting of P-G-S-A (SEQ ID NO:19) and an excipient.
3. A composition-comprising:
a polypeptide consisting of P-G-S-A (SEQ ID NO:19) bonded to a label.
4. The composition of claim 3 , wherein said label is selected from the group consisting of FITC, biotin, rhodamine, radioactive isotopes, and fluorescent nanocrystals.
5. A pharmaceutical composition comprising the amino acid sequence a polypeptide consisting of P-G-S-A (SEQ ID NO:19) and a pharmaceutically acceptable excipient.
6. A method of inducing the immune response of a patient comprising:
administering to said patient an effective amount of a polypeptide consisting of P-G-S-A (SEQ ID NO:19), wherein the amount of TH2 cytokines in said patient is increased.