Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
View Patent ↗The invention relates to compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds, wherein the compounds are of the following Formulas: or a pharmaceutically acceptable salt, ester or prodrug thereof, wherein the substituents are defined in the application. The invention further provides methods of treatment of inflammatory disorders by administering the compounds.
1. A compound of Formula II
or a pharmaceutically acceptable salt or ester thereof, wherein:
Y is selected from the group consisting of:
or a compound selected from the group consisting of
or a pharmaceutically acceptable salt or ester thereof.
2. The compound of claim 1 wherein the compound is a compound of Formula II wherein
Y is
or a pharmaceutically acceptable salt or ester thereof.
3. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.
4. A method for the treatment of an inflammatory disorder, comprising administering an effective amount of a compound of claim 1 .
5. The method of claim 4 , wherein the disorder is arthritis.
6. The method of claim 4 , wherein the disorder is rheumatoid arthritis.
7. The method of claim 4 , wherein the disorder is asthma.
8. The method of claim 4 , wherein the disorder is allergic rhinitis.
9. The method of claim 4 , wherein the disorder is chronic obstructive pulmonary disease.
10. The method of claim 4 , wherein the disorder is atherosclerosis.
11. The method of claim 4 , wherein the disorder is restenosis.
12. A method for inhibiting the expression of VCAM-1, comprising administering an effective amount of a compound of claim 1 .
13. The compound of claim 1 wherein the compound is a compound of Formula II and Y is
or a pharmaceutically acceptable salt or ester thereof.
14. The compound of claim 1 wherein the compound is:
or a pharmaceutically acceptable salt or ester thereof.
15. The compound of claim 1 wherein the compound is:
or a pharmaceutically acceptable salt or ester thereof.
16. The compound of claim 1 wherein the compound is:
or a pharmaceutically acceptable salt or ester thereof.
17. The pharmaceutical composition of claim 3 , in a form suitable for oral, parenteral, intravenous, intradermal, transdermal, subcutaneous or topical administration.
18. The pharmaceutical composition of claim 3 , wherein the compound is in the form of a dosage unit.
19. The pharmaceutical composition of claim 3 , wherein the dosage unit contains about 0.5–1000 mg of the compound.
20. The pharmaceutical composition of claim 3 , in the form of a tablet or capsule.
21. The pharmaceutical composition of claim 3 , wherein the compound is a compound of Formula II
or a pharmaceutically acceptable salt or ester thereof.
22. The pharmaceutical composition of claim 3 , wherein the compound is a compound of Formula II
or a pharmaceutically acceptable salt or ester thereof.
23. The pharmaceutical composition of claim 3 , wherein the compound is
or a pharmaceutically acceptable salt or ester thereof.
24. The pharmaceutical composition of claim 3 , wherein the compound is
or a pharmaceutically acceptable salt or ester thereof.
25. The pharmaceutical composition of claim 3 , wherein the compound is
or a pharmaceutically acceptable salt or ester thereof.