Contrast agents for myocardial perfusion imaging
View Patent ↗The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.
1. A contrast agent of formula (IV)
wherein
n, m, and o are independently 1, 2, 3, or 4;
Z is O, S, or NR 46 ;
R 45 is an imaging moiety or C 1 -C 4 alkyl optionally substituted with an imaging moiety;
R 45 is hydrogen or C 1 -C 3 alkyl;
Ar is phenyl, furyl, thienyl, oxazolinyl, isoxazolinyl, thiazolyl, isothiazolyl, pyridyl, naphthyl, pyrimidinyl, or pyrazinyl;
G is absent or O; and
L is an imaging moiety;
provided that when G is absent, o is 3.
2. A contrast agent which is
3. A contrast agent which is