Method for the production of a blood component composition
View Patent ↗A system for the production of a blood component composition is provided. The system includes a centrifuge having a blood reservoir for receiving and separating a blood sample into multiple components; a dispenser disposed outside of the centrifuge having a first collection chamber containing an activation agent and a second collection chamber containing one or more medicinal agents; means for removing a first portion at least one separated blood component from the centrifuge to the first container and a second portion to the second collection chamber, wherein the first collection chamber activates the first portion and stores the resulting clot and thrombin; a filter for separating the thrombin from the clot; and a nozzle for entraining and mixing the thrombin with the second portion containing the one or more medicinal components.
1. A system of the production of a blood component composition, comprising:
a centrifuge including a blood reservoir for receiving and separating an anticoagulated blood sample having multiple inactive blood components;
a dispenser being disposed outside of the centrifuge and the blood reservoir and having first collection chamber containing an activation agent and a second collection chamber containing one or more medicinal materials;
means for removing at least one of the inactive blood component upon separation from the centrifuge and delivering a first portion of the inactive blood component to the first collection chamber and a second portion of the inactive blood component to the second collection chamber, the first collection chamber activating the first portion of the inactive blood component and storing a resulting activated blood component comprising a clot and thrombin, the second collection chamber combining the second portion of the inactive blood component with the one or more medicinal materials;
a filter for separating the thrombin from the clot; and
a nozzle for entraining and mixing the thrombin with the second portion of the inactive blood component comprising the one or more medicinal materials thereby forming the blood component composition.
2. The system of claim 1 , wherein the blood sample is separated into various inactive blood components comprising a red blood cell component, a white blood cell component, a platelet rich plasma component and a platelet poor plasma component.
3. The system of claim 1 , wherein the first collection chamber contains a restoration agent.
4. The system of claim 3 , wherein the restoration agent is a calcium salt or an anti-heparmn agent.
5. The system of claim 4 , wherein the calcium salt is calcium chloride, calcium gluconate, or calcium carbonate.
6. The system of claim 4 , wherein the anti-heparin agent is heparinase or protamine.
7. The system of claim 1 , wherein the activation agent is glass wool, silica, aluminum, diatomaceous earth, kaolin, plastic, siliconized glass or a chemical activator.
8. The system of claim 1 , wherein the one or more medicinal materials are selected from the group consisting of drugs, analgesic compounds, antibacterial compounds, antibiotics, antifungal compounds, anti-inflammatories, antiparasitic compounds, antiviral compounds, anticancer compounds, genetic agents, enzyme inhibitors, glycoproteins, growth factors, hormones, steroids, glucocorticosteroids, immunomodulators, immunoglobulins, minerals, neuroleptics, proteins, peptides, lipoproteins, tumoricidal compounds, tumorstatic compounds, toxins, vitamins, bone, gelatin, collagen, degradable polymers, hyaluronic acid, carbohydrates and starches.
9. The system of claim 1 , wherein the means for removing at least one of said separated inactive blood component from the centrifuge and delivering a first portion of the inactive blood component to the first collection chamber and a second portion of the inactive blood component to the second collection chamber comprises a lumen.