Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
View Patent ↗The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting p38α MAP kinase and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-CoA reductase, or both for use in the practice of the present invention.
1. A compound comprising formula VII:
wherein R 1 is
n being 0 or any integer;
R 2 is optionally substituted alkyl, aryl, or heteroaryl;
R 3 is any substituent;
R 4 is optionally substituted
optionally substituted
or substituted
and R 5 is optionally substituted aryl or heteroaryl, or a salt thereof.
2. The compound as recited in claim 1 wherein R 2 is a C 3-4 branched alkyl group.
3. The compound as recited in claim 1 wherein R 2 is isopropyl.
4. The compound as recited in claim 1 wherein R 4 is
5. The compound as recited in claim 1 wherein R 5 is an optionally substituted phenyl group.
6. The compound as recited in claim 1 wherein R 5 is 4-fluorophenyl.
7. The compound as recited in claim 1 wherein R 3 is —CONH-aryl.
8. The compound as recited in claim 1 wherein R 3 is —CONH-phenyl.
9. A compound comprising at least one structure selected from:
a salt and/or a solvate thereof.
10. A compound comprising at least one structure selected from:
a salt and/or a solvate thereof.
11. A compound comprising at least one structure selected from:
a salt and/or a solvate thereof.
12. A compound comprising at least one structure selected from:
a salt and/or a solvate thereof.
13. A compound comprising formula VII:
wherein R 1 is
n being 0 or any integer;
R 2 is optionally substituted alkyl, aryl, or heteroaryl;
R 3 is any substituent;
R 4 is substituted
wherein said R 4 is substituted with one or more optionally substituted amino groups or optionally
substituted alkoxy groups;
and R 5 is optionally substituted aryl or heteroaryl, or a salt thereof.
14. A compound comprising formula VIIa:
wherein R 1 is
n being 0 or any integer;
R 2 is optionally substituted alkyl, aryl, or heteroaryl;
the pyridinyl ring is substituted;
and R 5 is optionally substituted aryl or heteroaryl, or a salt thereof.
15. A compound comprising formula VIIb:
wherein R 1 is
n being 0 or any integer;
R 2 is optionally substituted alkyl, aryl, or heteroaryl;
the pyrimidinyl ring is optionally substituted;
and R 5 is optionally substituted aryl or heteroaryl, or a salt thereof.