Selfassembled grafted polymeric layer for use in biosensor technology
View Patent ↗A water soluble functional polyethylene glycol-grafted polysiloxane polymer comprising a polysiloxane backbone and polyethylene glycol side chains is provided having the general formula: wherein A is selected from the group consisting of hydrogen, methyl, methoxy and functional polyethylene glycol based chains, B is a functional group for binding biologically-sensitive materials, D is a functional group for binding to a substrate, m is from 3 to 5, v is from 0 to 5, w is from 4 to 11, x is from 0 to 35 and z is from 1 to 33. In order to be water soluble, the polysiloxane polymer h the following properties: x+y+z is from 8 to 40, n is from 8 to 30, and y is from 7 to 35.
1. A water-soluble functional polyethylene glycol-grafted polysiloxane polymer comprising a polysiloxane backbone and functional polyethylene glycol side chains, the polymer having the general formula:
wherein A is hydrogen, B is a carboxyl group capable of binding to a biologically-sensitive material, D is a S—S—CH 2 —CH 3 group capable of binding to a substrate, m is an integer from 3 to 5, v is an integer from 0 to 5, w is an integer from 4 to 11, x is 11, and z is 6, wherein
x+y+z is an integer from 8 to 40,
n is an integer from 8 to 30, and
y is 18.
2. The water-soluble functional polyethylene glycol-grafted polysiloxane polymer according to claim 1 , wherein n is an integer from 10 to 30.
3. The water-soluble functional polyethylene glycol-grafted polysiloxane polymer according to claim 1 , wherein v is an integer from 1 to 3.
4. The water-soluble functional polyethylene glycol-grafted polysiloxane polymer according to claim 1 , wherein m is 3, n is 25, v is 1, and w is 11.