IP Library Granted Patent US 8,571,648
Granted Patent B2
US 8,571,648 · App. 11/123,599 · Granted Oct 29, 2013

Apparatus and method to apply substances to tissue

Inventors: Robert S. Anderson (Livermore, CA); Steve Young (Discovery Bay, CA)
Assignee: Aesthera
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Quick Facts
Patent No.
US 8,571,648
App. No.
11/123,599
Granted
Oct 29, 2013
Kind
B2
Abstract

Methods and apparatuses to apply substances to a biological tissue are described. The tissue having an target below a surface is stretched to provide openings in a surface. Stretching forces a material from the target onto the surface. A first substance may be applied while stretching to promote cleaning the tissue. A second substance may be applied to the surface. Energy may be applied to the tissue. Then the tissue is relaxed to draw the second substance through the openings into the tissue. The tissue may be stretched by applying a negative pressure, and relaxed by removing the negative pressure. The first substance may be an abrasive material. The second substance is a medicine, a moisturizer, a lotion, or any combination thereof. The second substance may be applied to the biological tissue using a positive pressure. The apparatus to apply substances may be a handheld device.

Claims (42)

1. A system to treat a biological tissue, comprising:

means for stretching a biological tissue having a substance on a surface and a target below the surface; and

means for relaxing the biological tissue to draw the substance from the surface into the biological tissue; and wherein the means for stretching comprises:

a vacuum source;

a vacuum conduit within a housing, the vacuum conduit coupled to the vacuum source;

a controller coupled to the vacuum source to apply a vacuum to stretch the surface; and

wherein the housing includes a first substance supplier through which the substance is applied onto the surface of the biological tissue and wherein the housing has an opening to receive the biological tissue; and

wherein the means for relaxing comprises the controller which is configured to stop applying the vacuum to remove the stretching of the surface of the biological tissue after the substance is applied onto the surface; and

wherein the controller coupled to the vacuum source is configured to apply the vacuum to stretch the surface that includes an epidermis that opens pathways in the epidermis, and exposes an inner surface of the target including sebaceous glands through the pathways, and wherein the controller is configured to provide the stretching that when removed generates a force that pushes the substance from the epidermis further down to the sebaceous glands.

2. The system of claim 1 , wherein the vacuum is less than 400 torr.

3. The system of claim 1 , wherein the substance, contained in the first substance supplier, is a medicine, a moisturizer, water, an alcohol, a lotion, or any combination thereof.

4. The system of claim 1 further comprising

means for applying an energy to the biological tissue.

5. The system of claim 4 , wherein the energy is a light, a radio frequency, an ultrasound, or any combination thereof.

6. The system of claim 1 , further comprising

means for providing a positive pressure to apply the substance onto the surface of the biological tissue.

7. The system of claim 1 , wherein the system to treat the biological tissue comprises a handheld system.

8. A system to treat a biological tissue, comprising:

a vacuum system configured to create a vacuum to stretch a biological tissue having a surface and a target below the surface, to provide openings in the surface, wherein the surface includes an epidermis, and the target includes sebaceous glands;

a substance conduit configured to apply a first substance to the surface while stretching the surface to promote cleaning of the surface;

means for applying a second substance to the surface;

a housing coupled to the substance conduit and to the vacuum system, the housing having an opening to receive the surface while it is stretching;

a controller coupled to the vacuum source, wherein the controller and the vacuum source are configured to apply a sufficient vacuum to stretch the surface in order to open pathways in the epidermis and in order to expose inner surfaces of sebaceous glands through the pathways and wherein the controller is configured to stop applying the vacuum to the surface to remove the stretching of the surface, after the first substance is applied, in order to relax the surface, wherein the controller is configured to provide the stretching that when removed provides a force that pushes the second substance from the epidermis further down to the sebaceous glands.

9. The system of claim 8 , wherein the first substance includes an abrasive material.

10. The system of claim 8 , wherein the second substance is a medicine, moisturizer, water, an alcohol, a lotion, or any combination thereof.

11. The system of claim 8 , wherein the vacuum is less than 400 torr.

12. The system of claim 1 , the system further comprising a pressure sensor coupled to the controller and wherein the controller and the pressure sensor are configured to sense a positive pressure when the housing is applied to the surface and the controller is configured, in response to the sensing of the positive pressure, to apply the vacuum to the surface.

13. The system of claim 8 , the system further comprising a pressure sensor coupled to the controller and wherein the controller and the pressure sensor are configured to sense a positive pressure when the housing is applied to the surface and the controller is configured, in response to the sensing of the positive pressure, to apply the vacuum to the surface.

14. The system of claim 5 wherein the energy is a light energy produced by a handheld system, and the system to treat the biological tissue comprises the handheld system and wherein the controller is configured to cause the means for applying the energy to apply the light energy before the substance is applied onto the surface of the biological tissue.

15. The system of claim 8 further comprising:

a light source coupled to the housing, the light source being configured to generate light to treat the biological tissue; and wherein the system to treat the biological tissue comprises a handheld system through which the light is applied to treat the biological tissue and through which the first substance is applied to the biological tissue.

16. The system of claim 1 , wherein the controller is configured to apply the vacuum that lifts the target up from a first position below the surface to a second position closer to the surface.

17. The system of claim 1 , wherein the first substance supplier is a pad against which the biological tissue is pulled up when the vacuum is applied.

18. The system of claim 1 , wherein the first substance supplier is a conduit.

19. The system of claim 1 , wherein the housing includes a second substance supplier.

20. The system of claim 1 , further comprising an article coupled to the housing to reduce a blood concentration in the biological tissue.

21. The system of claim 8 , wherein the controller is configured to apply the vacuum that lifts the target up from a first position below the surface to a second position closer to the surface.

22. The system of claim 8 , wherein the first substance supplier is a pad against which the biological tissue is pulled up when the vacuum is applied.

23. The system of claim 8 , wherein the first substance supplier is a conduit.

24. The system of claim 8 , further comprising a substance supplier for the second substance.

25. The system of claim 8 , further comprising an article coupled to the housing to reduce a blood concentration in the biological tissue.

26. The system of claim 13 , wherein the substance includes one of a benzoyl peroxide, a salicylic acid, an azelaic acid, a sulfacetamide-sulfer, and an erythromycin.

Assignments (20)
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: BAUSCH HEALTH AMERICAS, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.
Reel/Frame 073637/0126 →
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: BAUSCH HEALTH COMPANIES INC.; BAUSCH HEALTH, CANADA INC.; BAUSCH HEALTH IRELAND LIMITED; SOLTA MEDICAL IRELAND LIMITED
Reel/Frame 073654/0300 →
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH AMERICAS, INC.
Reel/Frame 073654/0242 →
U.S. PATENT SECURITY AGREEMENT Recorded Jun 13, 2025
From: MEDICIS PHARMACEUTICAL CORPORATION; ORAPHARMA, INC.; BAUSCH HEALTH US, LLC (F/K/A VALEANT PHARMACEUTICALS NORTH AMERICA LLC); PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, INC.; SANTARUS, INC.; BAUSCH HEALTH AMERICAS, INC.; SOLTA MEDICAL, INC.
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 071566/0200 →
U.S. PATENT SECURITY AGREEMENT Recorded Jun 13, 2025
From: MEDICIS PHARMACEUTICAL CORPORATION; ORAPHARMA, INC.; BAUSCH HEALTH US, LLC (F/K/A VALEANT PHARMACEUTICALS NORTH AMERICA LLC); PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, INC.; SANTARUS, INC.; BAUSCH HEALTH AMERICAS, INC.; SOLTA MEDICAL, INC.
To: THE BANK OF NEW YORK MELLON
Reel/Frame 071564/0463 →
RELEASE OF SECURITY INTEREST Recorded Apr 8, 2025
From: BARCLAYS BANK PLC, AS COLLATERAL AGENT
To: SOLTA MEDICAL, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH IRELAND LIMITED (F/K/A/ VALEANT PHARMACEUTICALS IRELAND LIMITED); SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD; SANTARUS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; HUMAX PHARMACEUTICAL S.A.; SOLTA MEDICAL IRELAND LIMITED; BAUSCH & LOMB MEXICO, S.A. DE C.V.; BAUSCH+LOMB OPS B.V.; BAUSCH HEALTH AMERICAS, INC.; BAUSCH HEALTH COMPANIES INC.; BAUSCH HEALTH HOLDCO LIMITED; BAUSCH HEALTH MAGYARORSZAG KFT (A/K/A BAUSCH HEALTH HUNGARY LLC); BAUSCH HEALTH POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (F/K/A VALEANT PHARMA POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA); BAUSCH HEALTH US, LLC; BAUSCH HEALTH, CANADA INC. / SANTE BAUSCH, CANADA INC.; ICN POLFA RZESZOW SPOLKA AKCYJNA (A/K/A ICN POLFA RZESZOW S.A.); ORAPHARMA, INC.; PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA SPOLKA AKCYJNA (A/K/A PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA S.A.); SOLTA MEDICAL DUTCH HOLDINGS B.V.; V-BAC HOLDING CORP.; VRX HOLDCO LLC; 1261229 B.C. LTD.; 1530065 B.C. LTD.
Reel/Frame 070778/0199 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Jun 9, 2023
From: BAUSCH HEALTH IRELAND LIMITED; SOLTA MEDICAL IRELAND LIMITED; MEDICIS PHARMACEUTICAL CORPORATION; ORAPHARMA, INC.; SALIX PHARMACEUTICALS, INC.; SOLTA MEDICAL, INC.; PRECISION DERMATOLOGY, INC.
To: BARCLAYS BANK PLC, AS COLLATERAL AGENT
Reel/Frame 063942/0001 →
SECURITY AGREEMENT (SECOND LIEN) Recorded Oct 5, 2022
From: BAUSCH HEALTH US, LLC; BAUSCH HEALTH AMERICAS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; SOLTA MEDICAL, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 061606/0468 →
SECURITY AGREEMENT (FIRST LIEN) Recorded Oct 4, 2022
From: BAUSCH HEALTH US, LLC; BAUSCH HEALTH AMERICAS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; SOLTA MEDICAL, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 061595/0066 →
SECURITY INTEREST Recorded Jun 13, 2022
From: BAUSCH HEALTH COMPANIES INC.; BAUSCH HEALTH, CANADA INC.; BAUSCH HEALTH IRELAND LIMITED; SOLTA MEDICAL IRELAND LIMITED
To: THE BANK OF NEW YORK MELLON
Reel/Frame 060346/0705 →
SECURITY AGREEMENT Recorded Feb 10, 2022
From: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH AMERICAS, INC.
To: THE BANK OF NEW YORK MELLON
Reel/Frame 059121/0001 →
SECURITY INTEREST Recorded Jun 8, 2021
From: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH AMERICAS, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 056811/0814 →
MERGER Recorded May 13, 2021
From: AESTHERA; LIPOSONIX, INC.
To: SOLTA MEDICAL, INC.
Reel/Frame 056227/0174 →
SECURITY INTEREST Recorded Mar 11, 2019
From: BAUSCH HEALTH AMERICAS, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 048556/0758 →
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Jan 23, 2014
From: SILICON VALLEY BANK
To: AESTHERA CORPORATION
Reel/Frame 032123/0736 →
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Jan 23, 2014
From: CAPITAL ROYALTY PARTNERS II L.P.; CAPITAL ROYALTY PARTNERS II - PARALLEL FUND "A" L.P.; PARALLEL INVESTMENTS OPPORTUNITIES PARTNERS II L.P.
To: AESTHERA CORPORATION
Reel/Frame 032123/0720 →
SHORT-FORM PATENT SECURITY AGREEMENT Recorded Nov 19, 2013
From: AESTHERA CORPORATION
To: CAPITAL ROYALTY PARTNERS II L.P.; CAPITAL ROYALTY PARTNERS II - PARALLEL FUND "A" L.P.; PARALLEL INVESTMENT OPPORTUNITIES PARTNERS II L.P.
Reel/Frame 031674/0608 →
SECURITY AGREEMENT Recorded Apr 25, 2013
From: AESTHERA CORPORATION
To: SILICON VALLEY BANK
Reel/Frame 030294/0003 →
SECURITY INTEREST - MEZZANINE LOAN Recorded Apr 25, 2013
From: AESTHERA CORPORATION
To: SILICON VALLEY BANK
Reel/Frame 030294/0021 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 6, 2005
From: ANDERSON, ROBERT S.; YOUNG, STEVE
To: AESTHERA
Reel/Frame 016537/0752 →
Continuity (3)
Continuation In Part 11024340 · Dec 27, 2004
Continuation In Part 10841273 · May 7, 2004
Related Publication 20060189964A1 · Aug 24, 2006