Method of modulating the activity of functional immune molecules
View Patent ↗The invention relates to a method for controlling the activity of an immunologically functional molecules, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having promoted activity.
1. An antibody composition comprising antibody molecules, wherein 100% of the antibody molecules comprising a Fc region comprising complex N-glycoside-linked sugar chains bound to the Fc region through N-acetylglucosamine of the reducing terminal of the sugar chains do not contain sugar chains with a fucose bound to the N-acetylglucosamines.
2. The antibody composition according to claim 1 wherein the antibody molecule is a molecule selected from the group consisting of (a), (b) and (c):
(a) a human antibody;
(b) a humanized antibody;
(c) an antibody fragment.
3. The antibody composition according to claim 1 , wherein the antibody molecule belongs to an IgG class.
4. The antibody composition according to claim 1 , wherein said antibody molecule binds to an antigen associated with cancer.
5. The antibody composition according to claim 4 , wherein said antibody molecule binds to a CD20 antigen.
6. The antibody composition according to claim 1 , wherein said antibody molecule is, except for the lack of fucose bound to the N-acetylglucosamines, rituximab.
7. A composition comprising the antibody composition according claim 1 and a carrier.