Pharmaceutical composition useful in prevention and treatment of beta-amyloid protein-induced disease
View Patent ↗The invention provides methods for treating beta-Amyloid protein-induced disease, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the invention relates to the use of natural product compounds isolated from turmeric, gingko biloba , and ginger, and synthetic chemical analogues thereof, for the treatment of a beta-Amyloid protein-induced disease.
1. A method for the treatment of a beta-Amyloid protein-induced cytotoxicity comprising administering to a subject suffering from the beta-Amyloid protein-induced cytotoxicity a therapeutically effective amount of a compound having the formula (IV):
or a pharmaceutically acceptable salt or ester thereof, wherein:
R is selected from the group consisting of higher alkyl, higher alkenyl, and higher alkynyl.
2. The method according to claim 1 wherein:
R is
n is 1-7.
3. The method according to claim 1 wherein:
R is selected from the group consisting of
4. The method according to claim 1 wherein the beta-Amyloid induced disease is Alzheimer's Disease.
5. The method according to claim 1 in which the beta-amyloid protein-induced cytotoxicity is neurotoxicity.
6. The method according to claim 1 wherein a purified and isolated compound selected from the group consisting of formula (IV) is administered.