Combination therapy for glaucoma treatment
View Patent ↗A method is disclosed herein comprising administering a compound and a second drug to an eye of a mammal for the treatment of glaucoma or the reduction of intraocular pressure, said compound represented by the general formula I; wherein A, B, D, X, Y, Z, R 1 , R 3 and R 4 are as defined in the specification.
1. A method comprising administering a compound and a second drug to an eye of a mammal for the treatment of glaucoma or the reduction of intraocular pressure, said compound being represented by the general formula I:
wherein the hatched lines represent the α configuration, a triangle represents the β configuration, a wavy line represents either the α or β configuration and a dotted line represents the presence or absence of a double bond;
A and B are S;
D represents a covalent bond;
X is CO 2 R;
Y is O;
Z is a covalent bond;
R is H;
R 1 is H;
R 3 is benzothienyl and R 4 is hydrogen.
2. The method of claim 1 wherein said second drug is selected from the group consisting of β-blockers, adrenergic agonists, α 2 -slective adrenergic agonists, carbonic anhydrase inhibitors, cholinertic agonists, glutamate antagonists, prostamides, prostagalandins, cannabinoids, and combinations thereof.