Intraluminal medical devices in combination with therapeutic agents
View Patent ↗Medical devices may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
1. An aneurysm repair device comprising:
at least one bypass prosthesis configured to establish a fluid flow path through an aneurysmal section of an artery;
a basecoat affixed to at least a portion of the at least one bypass prosthesis, the basecoat comprising a fluoropolymer PVDF/HFP in a ratio of 60 percent by weight of PVDF to 40 percent by weight of HFP;
at least one anti-inflammatory agent incorporated into the basecoat, the anti-inflammatory agent comprising a rapamycin; and
a topcoat affixed to the basecoat for controlling the elution of the rapamycin from the basecoat into the surrounding tissue, the topcoat comprising an at least 150 micro grams acrylic polymer BMA layer coated directly onto the basecoat, wherein the acrylic polymer BMA and the fluoropolymer PVDF/HFP are immiscible and chemically incompatible polymers such that the basecoat and topcoat do not blend and are affixed as separate and distinct layers upon each other to create a physical and chemical barrier to the elution of the rapamycin.