Urea substituted imidazoquinoline ethers
View Patent ↗Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and urea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
1. A method of inducing cytokine biosynthesis in an animal comprising administering a compound selected from the group consisting of N-(2-{2-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethoxy}ethyl)-N′-phenylurea and N-(2-{2-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethoxy}ethyl)-N-methyl-N′-phenylurea, or a pharmaceutically acceptable salt thereof to the animal in need thereof an amount effective for cytokine induction.
2. The method of claim 1 wherein the cytokine is IFN-α and/or TNF-α.