Granted Patent
B2
US 8,454,946 · App. 11/134,076 · Granted Jun 4, 2013
N-maleimidyl polymer derivatives
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Abstract
The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives.
Claims (2)
1. A multi-functional polymer derivative of structure
wherein n is from about 3 to about 4000.
Assignments (6)
RELEASE OF SECURITY INTEREST
Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL 28571, FRAME 0141
Recorded Oct 14, 2015
From: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 036866/0700 →
GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS
Recorded Oct 6, 2015
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 036796/0562 →
GRANT OF SECURITY INTEREST
Recorded Jul 17, 2012
From: NEKTAR THERAPEUTICS
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 028571/0141 →
MERGER
Recorded Aug 31, 2009
From: NEKTAR THERAPEUTICS AL, CORPORATION
To: NEKTAR THERAPEUTICS
Reel/Frame 023196/0394 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 24, 2009
From: SHEN, XIAOMING
To: NEKTAR THERAPEUTICS AL, CORPORATION
Reel/Frame 022595/0836 →