LbL-coated medical device and method for making the same
View Patent ↗The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.
1. A method for producing a medical device having a biocompatible LbL coating, comprising the steps of:
(a) contacting said medical device with a solution of a charged polymeric material to form a layer of the charged polymeric material,
(b) optionally rinsing said medical device by contacting said medical device with a rinsing solution;
(c) contacting said medical device with a solution of a non-charged polymeric material to form a layer of the non-charged material on top of the layer of the charged polymeric material, wherein the non-charged polymeric material is capable of being non-covalently bond to the charged polymeric material in said biocompatible LbL coating; and
(d) optionally rinsing said medical device by contacting said medical device with the rinsing solution,
wherein said charged polymeric material is a first polyanionic polymer or a mixture of two or more polyanionic polymers, and wherein said non-charged material is a homopolymer of a vinyl lactam of formula (I), a copolymer of at least one vinyl lactam of formula (I) in the presence or in the absence of one or more hydrophilic vinylic comonomers, or mixture thereof
wherein
R is an alkylene di-radical having from 2 to 8 carbon atoms,
R 1 is hydrogen, C 1 -C 10 alkyl, aryl having up to 10 carbon atoms, aralkyl or alkaryl having up to 14 carbon atoms, and
R 2 is hydrogen or C 1 -C 10 alkyl.
2. A method of claim 1 , wherein at least one of said contacting occurs by immersion said medical device in a solution.
3. A method of claim 1 , wherein at least one of said contacting occurs by spraying a solution onto the medical device.
4. A method of claim 1 , wherein said method comprises repeating steps (a) through (d) between 3 to 20 times.
5. A method of claim 1 , comprising a step of contacting the medical device with a first-dipping solution of a charged polymeric material to form an innermost layer of said coating on the surface of the medical device, wherein the concentration of the charged material in the first-dipping solution is sufficiently high enough to increase the hydrophilicity of the LbL coating.