Substituted triazoles as modulators of PPAR and methods of their preparation
The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
1. A compound having the formula:
wherein
Ar 1 is phenyl, which is optionally substituted with from one to five R 7 substituents independently selected from the group consisting of halogen, (C 1 -C 8 )alkyl, halo(C 1 -C 8 )alkyl, and —OR 2 ;
Ar 2 is phenyl, which is optionally substituted with from one to four R 8 substituents independently selected from the group consisting of halogen, (C 1 -C 8 )alkyl, halo(C 1 -C 8 )alkyl, and —OR 2 ;
L is a member selected from the group consisting of —CH 2 S— and —CH 2 O—;
K is a member selected from the group consisting of a covalent bond and —OCH 2 —
Z is CO 2 R 6 ;
R 1 is selected from the group consisting of H and (C 1 -C 8 )alkyl;
each R 2 and R 3 is a member independently selected from the group consisting of H, (C 1 -C 8 )alkyl, halo(C 1 -C 8 )alkyl, —X 3 OR 9 , aryl, aryl(C 1 -C 4 )alkyl, and heteroaryl, or optionally, if both present on the same substituent, may be joined together to form a three- to eight-membered ring system;
R 6 is a member selected from the group consisting of H, (C 1 -C 8 )alkyl, halo(C 1 -C 8 )alkyl, —X 4 OR 2 , —X 4 NR 2 R 3 , (C 2 -C 8 )alkenyl, (C 3 -C 7 )cycloalkyl, heterocyclyl, aryl (C 1 -C 4 )alkyl; and aryl(C 2 -C 8 )alkenyl;
R 9 is a member selected from the group consisting of H, (C 1 -C 8 )alkyl, halo(C 1 -C 8 )alkyl, aryl, aryl(C 1 -C 4 )alkyl, and heteroaryl;
each X 3 and X 4 is a member independently selected from the group consisting of (C 1 -C 4 ) alkylene, (C 2 -C 4 )alkenylene, and (C 2 -C 4 )alkynylene; and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof.
2. A compound of claim 1 , wherein Ar 1 is phenyl optionally substituted with from one to three R 7 substituents independently selected from the group consisting of halogen, halo(C 1 -C 8 )alkyl, and —OR 2 .
3. A compound of claim 1 , wherein Ar 1 is
a member selected for the group consisting of:
wherein X is a halogen; and
the dashed line indicates the point of attachment to the remainder of the molecule.
4. A compound of claim 3 , wherein Ar 1 is
wherein the dashed line indicates the point of attachment to the remainder of the molecule.
5. A compound of claim 1 , wherein R 1 is (C 1 -C 8 )alkyl.
6. A compound of claim 5 , wherein R 1 is selected from the group consisting of CH 3 and CH(CH 3 ) 2 .
7. A compound of claim 5 , wherein R 1 is CH 3 .
8. A compound of claim 1 , wherein L is CH 2 S.
9. A compound of claim 1 , wherein K is OCH 2 .
10. A compound of claim 1 , wherein Z is CO 2 R 6 .
11. A compound of claim 10 , wherein R 6 is H.
12. A compound of claim 1 , wherein Ar 2 is phenyl optionally substituted with from one to three R 8 substituents each independently selected from the group consisting of halogen, (C 1 -C 8 )alkyl, halo(C 1 -C 8 )alkyl, and —OR 2 .
13. A compound of claim 12 , wherein Ar 2 is phenyl optionally substituted with from one to two R 8 substituents each independently selected from the group consisting of halogen, (C 1 -C 8 )atkyl, halo(C 1 -C 8 )alkyl, and —OR 2 .
14. A compound of claim 12 , wherein L is (CH 2 )S.
15. A compound of claim 12 , wherein K is OCH 2 .
16. A compound of claim 12 , wherein each R 8 substituent is independently selected from the group consisting of halogen, (C 1 -C 8 )alkyl, and halo(C 1 -C 8 )alkyl.
17. A compound of claim 12 , wherein Ar 2 has the formula:
wherein the dashed line indicates the point of attachment to L and the wavy line indicates the point of attachment to K.
18. A compound of claim 17 , wherein the compound is
19. A compound selected from the group consisting of:
{2-Methyl-4-[5-methyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-phenoxy}-acetic acid; {4-[5-Methyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3 ]triazol-4-ylmethylsulfanyl]-phenoxy}-acetic acid; {2-Chloro-4-[5-methyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3 ]triazol-4-ylmethylsulfanyl]-phenoxy}-acetic acid; {4-[5-Methyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-trifluoromethyl -phenoxy}-acetic acid; {4-[5-Methyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-trifluoromethoxy-phenoxy}-acetic acid; 5- {2-Methyl-4-[5-methyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-phenoxymethyl}-1 H-tetrazole; {2-Bromo-4-[5-methyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3 ]triazol-4-ylmethylsulfanyl]-phenoxy}-acetic acid; {2-Methoxy-4-[5-methyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-phenoxy}-acetic acid; {2,6-Dimethyl-4-[5-methyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-phenoxy}-acetic acid; {2-Methyl-4-[5-methyl -2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-phenyl}-acetic acid; {4-[5-Isopropyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid; {2-Methyl-4-[5-propyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-phenoxy}-acetic acid; {2-Methyl-4-[5-phenyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-phenoxy}-acetic acid; {2-Methyl-4-[5-(2,2,2trifluoro-ethyl) -2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-phenoxy}-acetic acid; {2-Methyl-4-[5-trifluoromethyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl[-phenoxy}-acetic acid; {4-[2-(4-Chloro-phenyl)-5-methyl-2H-[1,2,3 ]triazol -4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid; {4-[2-(4-Bromo-phenyl)-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid; {4-[2-(3-Chloro-4-trifluoromethyl-phenyl)-5-methyl-2H-[1,2,3 ]triazol-4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid; {4-[2-(3,4-Bis-trifluoromethyl-phenyl)-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid; {4-[2-(4-Methoxy-phenyl)-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl[-2-methyl-phenoxy}-acetic acid; {2-Methyl-4-[5-methyl--2-(4trifluoromethoxy-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl[-phenoxy}-acetic acid; {4-[2-(4-Chloro-3-trifluoromethyl-phenyl)-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid; [4-(2-Benzo[1,3]dioxol-5-yl-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl)-2-methyl-phenoxy]-acetic acid; {2-Methyl-4-[5-methyl-2-(3-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-phenoxy}-acetic acid; {4-[2-(3-Chloro-phenyl)-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid; {4-[2-(3-Bromo-phenyl)-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid; {2-Ethyl-4-[5-methyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-phenoxy}-acetic acid; {2-Isopropyl-4-[5-methyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-phenoxy}-acetic acid; {4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid; {4-[2-(4-Fluoro-phenyl)-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid; {4-[2-(2-Flouro-4-trifluoromethyl-phenyl)-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid; {4-[2-(3,5-Bis-trifluoromethyl-phenyl)-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid; {4-[2-(3,4-Dichloro-phenyl)-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid; and {4-[2-(3,4-Difluoro-phenyl)-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid.
20. A compound selected from the group consisting of:
{4-[2-(3,5-Bis-trifluoromethyl-phenyl)-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid; {4-[2-(3,4-Dichloro-phenyl)-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid; [4-(2-Biphenyl-4-yl-5-methyl-2H-[1,2,3]triazol-4-ylmethylsulfanyl)-2-methyl-phenoxy]-acetic acid; {2-Methyl-4-[5-methyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazol-4-ylmethoxy]-phenoxy}-acetic acid and [4-(2-Biphenyl-4-yl-5-methyl-2H -[1,2,3]triazol-4-ylmethoxy)-2-methyl-phenoxy]-acetic acid.
21. A composition comprising one or more pharmaceutically acceptable caters, diluents, or excipients and a compound of claim 1 .