Immunoregulatory compounds and derivatives and methods of treating diseases therewith
View Patent ↗Compounds are disclosed having the structure of Formula I: where R 1 , R 3 , and R 4 are independently hydrogen or C 1 to C 4 alkyl, and R 2 is: where R 5 is selected from the group consisting of hydrogen and C 1 to C 4 alkyl, or where R 6 , R 7 and R 8 are independently hydrogen or C 1 to C 4 alkyl; or the esters or pharmacologically acceptable salts thereof. Such compounds may be utilized for the prophylaxis or treatment of various diseases, particularly inflammatory conditions of the GI tract. Methods of treating inflammatory conditions of the GI tract such as inflammatory bowel disease using compounds having the following formula are also disclosed: where R 9 , R 10 and R 11 are independently selected from the group consisting of hydrogen and C 1 to C 4 alkyl, and R 12 is selected from the group consisting of hydrogen and —C(O)R 13 , where R 13 is a C 1 to C 6 alkyl or an aryl group.
1. A pharmaceutical composition for treating an inflammatory condition of the gastrointestinal tract in a subject in need of such treatment, the composition comprising a 4-aminophenylacetic acid and/or ester or pharmaceutically acceptable salt thereof and a 5-aminosalicylic acid and/or ester or pharmaceutically acceptable salt thereof.
2. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition when administered to a subject in need thereof results in treatment of ulcerative colitis.
3. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition when administered to a subject in need thereof results in treatment of Crohn's disease.
4. The pharmaceutical composition of claim 1 , wherein the composition is formulated for oral administration.
5. The pharmaceutical composition of claim 1 , wherein the composition is formulated for rectal administration.