Method for treating tremor
View Patent ↗The present invention is directed to the use of a class of peptide compounds for treating essential tremor and other tremor syndromes.
1. A method for treating tremor in a subject in need thereof, the method comprising administering to the subject the compound (R)-2-acetamido-N-benzyl-3-methoxypropionamide or a pharmaceutically acceptable salt thereof, wherein the tremor comprises rhythmic oscillatory movement.
2. The method of claim 1 , wherein the tremor is selected from the group consisting of essential tremor, physiologic tremor, enhanced physiologic tremor, undetermined tremor syndrome, primary orthostatic tremor, dystonic tremor, task- and position-specific tremors, parkinsonian tremor syndromes, cerebellar tremor syndromes, Holmes's tremor, palatal tremors, neuropathic tremor syndrome, drug-induced and toxic tremor syndromes, psychogenic tremor, myorhythmia, rest tremor, action tremor, postural tremor, kinetic tremor, isometric tremor and combinations thereof.
3. The method of claim 1 , wherein the compound is administered in a pharmaceutical composition at a dose of the compound of at least 100 mg/day.
4. The method of claim 1 , wherein the compound is administered in a pharmaceutical composition at a dose of the compound not greater than 6 g/day.
5. The method of claim 1 , wherein the compound is administered in a pharmaceutical composition at increasing daily doses until a predetermined daily dose is reached which is maintained during further treatment.
6. The method of claim 1 , wherein the compound is administered in a pharmaceutical composition in no more than three doses per day.
7. The method of claim 1 , wherein the compound is administered in a pharmaceutical composition resulting in a plasma concentration of the compound of 0.1 to 15 μg/ml (trough) and 5 to 18.5 μg/ml (peak), calculated as an average over a plurality of treated subjects.
8. The method of claim 1 , wherein the compound is administered orally or intravenously in a pharmaceutical composition.
9. The method of claim 1 , further comprising administering to the subject a further active agent for the treatment of tremor.
10. The method of claim 9 , wherein the (R)-2-acetamido-N-benzyl-3-methoxypropionamide or salt thereof and the further active agent are administered in a single dose form or separate dose forms comprising a first composition comprising the (R)-2-acetamido-N-benzyl-3-methoxypropionamide or salt thereof and a second composition comprising the further active agent.
11. The method of claim 1 wherein the subject is a mammal.
12. The method of claim 11 wherein the subject is a human.
13. A pharmaceutical composition comprising
(a) (R)-2-acetamido-N-benzyl-3-methoxypropionamide or a pharmaceutically acceptable salt thereof, and
(b) a further active agent for the treatment of tremor.
14. The pharmaceutical composition according to claim 13 which is a single dose form or comprises separate dose forms comprising a first composition comprising the compound (a), and a second composition comprising the further active agent (b).