A bone paste useful in the orthopedic arts, for example in the repair of non-union fractures, periodontal ridge augmentation, craniofacial surgery, implant fixation, impaction grafting, or any other procedure in which generation of new bone is deemed necessary, is provided by a composition comprising a substantially bioabsorbable osteogenic compound in a gelatin matrix. In various embodiments, the osteogenic compound is selected from (i) demineralized bone matrix (DBM); (ii) bioactive glass ceramic, BIOGLASS®, bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, or like material; (iii) bone morphogenetic protein, TGF-β, PDGF, or mixtures thereof, natural or recombinant; and (iv) mixtures of (i)-(iii).
1. An implantable bone paste composition, for use in a recipient in need thereof, comprising a mixture of gelatin, osteogenic demineralized bone matrix (DBM) and, optionally, one or more additional substantially bioabsorbable, osteogenic components, wherein the optional osteogenic component is selected from the group consisting of:
bioactive glass ceramic, bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, bone morphogenetic protein, TGF-beta, PDGF, and mixtures thereof, and
wherein DBM is present at a concentration of from 24% (w/w) to 33% (w/w).
2. The composition of claim 1 wherein said composition gels at about 38° C.
3. The composition of claim 1 , which is a frozen solution or is freeze-dried.
4. The composition of claim 1 , wherein the demineralized bone matrix is in a powdered form, and is composed of particles in the size range between about 80-850μm in diameter.
5. An implantable bone paste composition, for use in a recipient in need thereof, consisting of a mixture of gelatin, osteogenic demineralized bone matrix (DBM), and optionally, a reconstitution solution, and/or one or more substantially bioabsorbable, osteogenic components, wherein the optional osteogenic component is selected from the group consisting of: bioactive glass ceramic, bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, bone morphogenetic protein, TGF-beta, PDGF, and mixtures thereof, and
wherein DBM is present at a concentration of from 24% (w/w) to 33% (w/w).
6. The composition of claim 1 , wherein said gelatin is present at a concentration of from about 20% (w/w) to about 45% (w/w).
7. The composition of claim 1 , comprising at least one osteogenic component selected from the group consisting of: bioactive glass ceramic, bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, bone morphogenetic protein, TGF-beta, PDGF, and mixtures thereof.
8. The composition of claim 7 , comprising bioactive glass ceramic and/or bone morphogenetic protein.
9. The composition of claim 3 , which is a frozen solution.
10. The composition of claim 3 , which is freeze-dried.
11. The composition of claim 5 , wherein said gelatin is present at a concentration of from about 20% (w/w) to about 45% (w/w).
12. The composition of claim 5 , wherein the demineralized bone matrix is in a powdered form, and is composed of particles in the size range between about 80-850 μm in diameter.
13. The composition of claim 5 , wherein said composition gels at about 38° C.
14. The composition of claim 5 , which is a frozen solution.
15. The composition of claim 5 , which is freeze-dried.