Photosensitizer formulations and their use
View Patent ↗A low concentration formulation for hydrophobic photosensitizers (PS) and method for photodynamic therapy (“PDT”) using the disclosed low concentration formulations provide for more accurate, more efficient and more convenient dosing. The inventive formulation (1) reduces the time for a therapeutically effective level of photosensitizer to accumulate in diseased tissue and (2) reduces the time for achieving a sufficient ratio of photosensitizer in diseased tissue vs. healthy tissue. The inventive formulation reduces the time interval between PS application/administration and irradiation (the drug-light interval or “DLI”) and can provide for a “same day” PDT treatment option. 0.08 mg/ml to 1.3 mg/ml meta Tetra-Hydroxy-Phenyl Chlorin (m-THPC) as the photosensitizer in a mixture of pure propylene glycol and ethanol (3:2 volume ratio) accumulates in diseased tissue and differentiates between diseased tissue and normal tissue sufficiently quickly for ‘one day’ or overnight administration and activation treatment procedures to be possible.
1. A low concentration photosensitizer formulation useful for systemic and other applications of photodynamic therapy of hyperproliferative tissue disease with specially enhanced pharmacokinetics and pharmacodynamics, comprising;
a hydrophobic photosensitizer in an alcoholic excipient mixture comprising propylene glycol and ethanol which solubilizes said hydrophobic photosensitizer;
and aqueous fluid;
wherein said photosensitizer is meta-tetra(hydroxyphenyl)chlorin (m-THPC); and
wherein said photosensitizer is present in a concentration of 0.08 mg/ml to 1.3 mg/ml in said alcoholic excipient mixture.
2. The low concentration formulation according to claim 1 , wherein said m-THPC is present in an amount ranging from about 0.08 mg/ml to 0.8 mg/ml.
3. The low concentration formulation according to claim 1 , wherein said alcoholic excipient mixture is propylene glycol and ethanol in a v/v ratio of 3:2.
4. A method of low concentration therapy for the PDT treatment of disease comprising the steps of:
a. administering at least one preselected dose of a photosensitizer in a low concentration formulation as described in claim 1 ;
b. allowing a period of time to allow said photosensitizer to preferentially accumulate in hyperproliferative tissue, generally less than 48 hours; and
c. applying radiation to said treatment area having a properly selected wavelength to activate said photosensitizer and render said photosensitizer toxic to tissue.
5. The method according to claim 4 wherein said period of time allowed is between 1-24 hours.
6. The method of claim 4 wherein said PDT treatment is started and completed within a 24 hour period.