IP Library › Granted Patent US 7,858,625
Granted Patent B2
US 7,858,625 · App. 11/166,717 · Granted Dec 28, 2010

Conjugates and compositions for cellular delivery

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Quick Facts
Patent No.
US 7,858,625
App. No.
11/166,717
Granted
Dec 28, 2010
Kind
B2
Abstract

This invention features conjugates, compositions, methods of synthesis, and applications thereof, including folate derived conjugates of nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids and antisense nucleic acid molecules.

Claims (4)

1. A compound having the formula below:

wherein each R 4 , R 5 , R 6 and R 7 is independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, or a protecting group, R 2 is a nucleic acid that is double stranded, each “n” is independently an integer from 0 to about 200, L is —P—O—CH 2 —(CH 2 ) n1 —CH 2 —S—S—CH 2 —CH 2 —NH—, “n1” is an integer from 0 to 20, and P is a phosphorus containing group.

2. The compound of claim 1 , having the formula below

wherein NA is a nucleic acid that is double stranded.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 17, 2009
From: MATULIC-ADAMIC, JASENKA; BEIGELMAN, LEONID
To: RIBOZYME PHARMACEUTICALS, INC.
Reel/Frame 022559/0510 →
CHANGE OF NAME Recorded Apr 17, 2009
From: RIBOZYME PHARMACEUTICALS, INC.
To: SIRNA THERAPEUTICS, INC.
Reel/Frame 022559/0560 →