Iontophoresis device
An iontophoresis device is capable of suppressing the change in a composition of a drug solution and/or an electrolyte solution of a working electrode structure, thereby allowing the working electrode structure to be retained in a stable state for a long period of time. The iontophoresis device includes: an electrolyte solution holding part for holding an electrolyte solution in which an electrolyte to be dissociated, in a solution, to first electrolytic ions of a first polarity and second electrolytic ions of a second polarity is dissolved; and a drug solution holding part for holding a drug solution in which a drug to be dissociated, in a solution, to the drug ions of the first polarity and drug counter ions of the second polarity is dissolved. A first ion-exchange membrane for selectively passing the ions of the second polarity and a porous separation membrane for blocking passage of molecules and ions each having a molecular weight exceeding a threshold are placed between the electrolyte solution holding part and the drug solution holding part.
1 . An iontophoresis device for administering drug ions to a living body, comprising:
an electrolyte solution holding part for holding an electrolyte solution in which an electrolyte to be dissociated, in a solution, to first electrolytic ions of a first polarity and second electrolytic ions of a second polarity opposite to the first polarity is dissolved; and
a drug solution holding part for holding a drug solution in which a drug to be dissociated, in a solution, to the drug ions of the first polarity and drug counter ions of the second polarity is dissolved, the drug solution holding part being placed on a front side of the electrolyte solution holding part,
wherein a first ion-exchange membrane for selectively passing the ions of the second polarity and a semi-permeable separation membrane for blocking passage of molecules and ions each having a molecular weight greater than a threshold molecular weight are placed between the electrolyte solution holding part and the drug solution holding part.
2 . The iontophoresis device according to claim 1 wherein the porous separation membrane blocks passage of the second electrolytic ions.
3 . The iontophoresis device according to claim 1 wherein the porous separation membrane blocks passage of one of the electrolyte molecules and the first electrolytic ions.
4 . The iontophoresis device according to claim 1 wherein the porous separation membrane blocks passage of one of the drug molecules and the drug ions.
5 . The iontophoresis device according to claim 1 wherein the electrolyte solution holding part is sealed in the porous separation membrane formed in a bag shape.
6 . The iontophoresis device according to claim 1 wherein the drug solution holding part is sealed in the porous separation membrane formed in a bag shape.
7 . An iontophoresis device for administering drug ions to a living body, comprising:
an electrolyte solution holding part for holding an electrolyte solution in which an electrolyte to be dissociated, in a solution, to first electrolytic ions of a first polarity and second electrolytic ions of a second polarity opposite to the first polarity is dissolved;
a drug solution holding part for holding a drug solution in which a drug to be dissociated, in a solution, to the drug ions of the first polarity and drug counter ions of the second polarity is dissolved, the drug solution holding part being placed on a front side of the electrolyte solution holding part; and
a first ion-exchange membrane for selectively passing ions of the second polarity, the first ion-exchange membrane being placed between the electrolyte solution holding part and the drug solution holding part, wherein the first ion-exchange membrane blocks passage of the second electrolytic ions.
8 . The iontophoresis device according to claim 7 , further comprising a second ion-exchange membrane for selectively passing the ions of the first polarity, the second ion-exchange membrane being placed on a front side of the drug solution holding part.
9 . An iontophoresis device for administering drug ions to a living body, comprising:
an electrolyte solution holding part for holding an electrolyte solution in which an electrolyte to be dissociated, in a solution, to first electrolytic ions of a first polarity and second electrolytic ions of a second polarity opposite to the first polarity is dissolved;
a drug solution holding part for holding a drug solution in which a drug to be dissociated, in a solution, to the drug ions of the first polarity and drug counter ions of the second polarity is dissolved, the drug solution holding part being placed on a front side of the electrolyte solution holding part; and
a first ion-exchange membrane for selectively passing ions of the second polarity, the first ion-exchange membrane being placed between the electrolyte solution holding part and the drug solution holding part,
wherein the first ion-exchange membrane blocks passage of one of the electrolyte molecules and the first electrolytic ions.
10 . The iontophoresis device according to claim 9 , further comprising a second ion-exchange membrane for selectively passing the ions of the first polarity, the second ion-exchange membrane being placed on a front side of the drug solution holding part.
11 . An iontophoresis device for administering drug ions to a living body, comprising:
an electrolyte solution holding part for holding an electrolyte solution in which an electrolyte to be dissociated, in a solution, to first electrolytic ions of a first polarity and second electrolytic ions of a second polarity opposite to the first polarity is dissolved;
a drug solution holding part for holding a drug solution in which a drug to be dissociated, in a solution, to the drug ions of the first polarity and drug counter ions of the second polarity is dissolved, the drug solution holding part being placed on a front side of the electrolyte solution holding part; and
a first ion-exchange membrane for selectively passing ions of the second polarity, the first ion-exchange membrane being placed between the electrolyte solution holding part and the drug solution holding part,
wherein the first ion-exchange membrane blocks passage of one of the drug molecules and the drug ions.
12 . The iontophoresis device according to claim 11 , further comprising a second ion-exchange membrane for selectively passing the ions of the first polarity, the second ion-exchange membrane being placed on a front side of the drug solution holding part.